Comparação do desempenho físico de indivíduos com e sem lipodistrofia generalizada congênita: um estudo transversal

Abstract

Objective: This study aimed to compare the physical performance of adult individuals with and without Congenital Generalized Lipodystrophy using the Short Physical Perfomance Battery (SPPB) scale. Method: This was a longitudinal cross-sectional study with a 1-year folow-up period only for LGC. It was applied to two groups: eleven healthy subjects and eleven with CGL, who were matched by gender and age. Categorical variables were analyzed using Pearson's chi-square test. A 5% significance level (α=0.05) was used for all analyses. This project was approved by the institutional Ethics Committee. Results: The results showed that individuals with LGC have reduced motor fitness when compared to healthy individuals (p<0.0001). When analyzing the separate SPPB scores, it was possible to see that the walking test score was the one that showed a significant reduction compared to the control group (p<0.0001), while no significant reduction was observed for the balance (p=0.214) and sitting (p=0.195) scores. Conclusion: Individuals with LGC showed lower motor fitness than healthy individuals, suggesting that loss-of-function mutations in seipin may affect the neuronal circuits involved with gait. Further studies using other methodologies are needed to confirm the reduction in motor skills of these subjects and, thus, establish physiotherapeutic protocols aimed at improving their motor skills.