Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review

Idalina Neta, Francisca; Costa, Ianara Mendonça da; Lima, Francisca Overlânia Vieira; Fernandes, Luciana Cristina Borges; Cavalcanti, José Rodolfo Lopes de Paiva; Freire, Marco Aurélio de Moura; Lucena, Eudes Euler De Souza; Rêgo, Amália Cinthia Meneses do; Araújo Filho, Irami; Azevedo, Eduardo Pereira de; Guzen, Fausto Pierdoná

Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review

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dc.contributor.author	Idalina Neta, Francisca
dc.contributor.author	Costa, Ianara Mendonça da
dc.contributor.author	Lima, Francisca Overlânia Vieira
dc.contributor.author	Fernandes, Luciana Cristina Borges
dc.contributor.author	Cavalcanti, José Rodolfo Lopes de Paiva
dc.contributor.author	Freire, Marco Aurélio de Moura
dc.contributor.author	Lucena, Eudes Euler De Souza
dc.contributor.author	Rêgo, Amália Cinthia Meneses do
dc.contributor.author	Araújo Filho, Irami
dc.contributor.author	Azevedo, Eduardo Pereira de
dc.contributor.author	Guzen, Fausto Pierdoná
dc.date.accessioned	2021-03-15T10:57:31Z
dc.date.available	2021-03-15T10:57:31Z
dc.date.issued	2018
dc.description.resumo	Introduction: Mucuna pruriens (L.)DC. (Mp) has been used in the treatment of numerous diseases in Indian Ayurvedic medicine, mainly for delaying the symptoms of Parkinson’s disease (PD), and has as its main component levodopa (L‑DOPA). The aim of this work is to systematically review the effects of Mp supplementation on experimental models of PD due to its neuroprotective and antioxidant properties. MATERIALS AND Methods: The search was conducted through PubMed, ScienceDirect, Cochrane Library, and Scientific Electronic Library Online databases, where a number of relevant articles were found. Results: Mp demonstrated significant positive responses in the experimental models of PD by improving motor deficits and by enhancing the activity of the antioxidant systems, reducing oxidative stress. In addition, it presented some advantages when compared to a conventional antiparkinsonian drug as it minimized the occurrence and severity of dyskinesias. Conclusion: Thus, considering that the use of herbal medicines decreases the likelihood of side effects associated with the pharmaceutical drugs, this work aims to summarize and evaluate the data available regarding the mechanism of action of Mp and the reported benefits of this plant as an alternative to improve the quality of life of individuals with PD	pt_BR
dc.identifier.citation	IDALINA NETA, Francisca et al. Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review. Pharmacognosy Reviews, [s. l.], v. 12, n. 23, p. 78, 2018. Medknow. Disponível em: http://www.phcogrev.com/article/2018/12/23/104103phrevphrev4617. Acesso em: 16 jul. 2020. http://dx.doi.org/10.4103/phrev.phrev_46_17	pt_BR
dc.identifier.doi	10.4103/phrev.phrev_46_17
dc.identifier.issn	0973-7847 (print)
dc.identifier.issn	0976-2787 (0nline)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31864
dc.language	en	pt_BR
dc.publisher	Medknow Publications	pt_BR
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/br/	*
dc.subject	Antioxidant	pt_BR
dc.subject	Mucuna pruriens (L.) DC	pt_BR
dc.subject	Neuroprotection	pt_BR
dc.subject	Parkinson’s disease	pt_BR
dc.title	Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review	pt_BR
dc.type	article	pt_BR