Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome

Soares, Nayara Pereira; Santos, Ana Celly Souza dos; Costa, Eduardo Caldas; Azevedo, George Dantas de; Damasceno, Débora Cristina; Fayh, Ana Paula Trussardi; Lemos, Telma Maria Araujo Moura

Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome

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dc.contributor.author	Soares, Nayara Pereira
dc.contributor.author	Santos, Ana Celly Souza dos
dc.contributor.author	Costa, Eduardo Caldas
dc.contributor.author	Azevedo, George Dantas de
dc.contributor.author	Damasceno, Débora Cristina
dc.contributor.author	Fayh, Ana Paula Trussardi
dc.contributor.author	Lemos, Telma Maria Araujo Moura
dc.date.accessioned	2021-02-19T16:38:07Z
dc.date.available	2021-02-19T16:38:07Z
dc.date.issued	2016-04-14
dc.description.resumo	Aims: we aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: a study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m2) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients	pt_BR
dc.identifier.citation	SOARES, Nayara Pereira; SANTOS, Ana Celly Souza dos; COSTA, Eduardo Caldas; AZEVEDO, George Dantas de; DAMASCENO, Débora Cristina; FAYH, Ana Paula Trussardi; LEMOS, Telma Maria Araújo Moura. Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome. Annals Of Nutrition And Metabolism, [s. l.], v. 68, n. 3, p. 220-227, 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27073909/. Acesso em: 18 fev. 2021. http://dx.doi.org/10.1159/000444130	pt_BR
dc.identifier.issn	0250-6807
dc.identifier.issn	1421-9697
dc.identifier.issn	10.1159/000444130
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31563
dc.language	en	pt_BR
dc.publisher	Karger Publishers	pt_BR
dc.rights	Attribution-NoDerivs 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nd/3.0/br/	*
dc.subject	Diet	pt_BR
dc.subject	DNA damage	pt_BR
dc.subject	Cardiometabolic risk factors	pt_BR
dc.subject	Overweight	pt_BR
dc.subject	Obesity	pt_BR
dc.subject	Polycystic ovary syndrome	pt_BR
dc.title	Diet-Induced weight loss reduces DNA damage and cardiometabolic risk factors in overweight/obese women with polycystic ovary syndrome	pt_BR
dc.type	article	pt_BR