Changes in immunoexpression of E-cadherin and beta-catenin in oral squamous cell carcinoma with and without nodal metastasis

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dc.contributor.authorLopes, Fernanda Ferreira
dc.contributor.authorMiguel, Marcia Cristina da Costa
dc.contributor.authorPereira, Antônio Luiz Amaral
dc.contributor.authorCruz, Maria Carmen Fontoura Nogueira da
dc.contributor.authorFreitas, Roseana de Almeida
dc.contributor.authorPinto, Leão Pereira
dc.contributor.authorSouza, Lelia Batista de
dc.date.accessioned2017-01-30T13:32:22Z
dc.date.available2017-01-30T13:32:22Z
dc.date.issued2009
dc.description.resumoThe aim of this study is to analyze the immunohistochemical expression of E-cadherin and beta-catenin in oral squamous cell carcinoma to better understand the biological behavior of this lesion. The sample consisted of 15 cases of the tongue and 15 of the lower lip. The pattern and intensity of the labeling and the analysis of the percentage of tumor cells immunopositive in membrane for E-cadherin and beta-catenin were related to the anatomic location of the lesion, the presence or absence of nodal metastasis, and the histological gradation of malignancy in the tumor invasion front. The presence or absence of cytoplasmic and nuclear labeling was also recorded. The membrane expression for E-cadherin and beta-catenin predominately displayed a heterogeneous pattern in the carcinomas studied. No significant difference was observed between the expression pattern and the quantity of cells immunopositive for E-cadherin and beta-catenin and the anatomic location of the lesion or the presence or absence of nodal metastasis. However, a statistically significant difference was found between the reduced expressio\n of these proteins and the high malignancy score. The reduced immunoexpression of these proteins in the membrane may be related to the high degree of cell indifferentiation in cases of oral squamous cell carcinoma with high scores.pt_BR
dc.identifier.citationLOPES, Fernanda Ferreira et al. Changes in immunoexpression of E-cadherin and beta-catenin in oral squamous cell carcinoma with and without nodal metastasis. Annals of Diagnostic Pathology, v. 13, n. 1, p. 22-29, 2009.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/21805
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSquamous cell carcinomapt_BR
dc.subjectOral cancerpt_BR
dc.subjectE-cadherinpt_BR
dc.subjectbeta-cateninpt_BR
dc.subjectImmunohistochemistrypt_BR
dc.titleChanges in immunoexpression of E-cadherin and beta-catenin in oral squamous cell carcinoma with and without nodal metastasispt_BR
dc.typearticlept_BR

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