Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis

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dc.contributor.authorAraújo Júnior, Raimundo Fernandes de
dc.contributor.authorSouza, Tatiana Oliveira
dc.contributor.authorMoura, Lígia Moreno de
dc.contributor.authorTorres, Kerginaldo Paulo
dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorAlves, Maria do Socorro Costa Feitosa
dc.contributor.authorRocha, Hugo Oliveira
dc.contributor.authorAraújo, Aurigena Antunes de
dc.date.accessioned2017-09-11T12:55:03Z
dc.date.available2017-09-11T12:55:03Z
dc.date.issued2013
dc.description.resumoThe aim of this study is to determine the effects of Atorvastatin treatment, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, in periodontal disease. Male Wistar albino rats were randomly divided into five groups of ten rats each: (1) non-ligated treatment (NL), (2) ligature only (L), (3) ligature plus 1 mg/kg Atorvastatin daily for 10 days, (4) ligature plus 5 mg/kg Atorvastatin daily for 10 days, and (5) ligature plus 10 mg/kg Atorvastatin daily for 10 days. Following the treatment course, the periodontal tissue of the animals was analyzed by Measurement of alveolar bone loss, Histopathology and immunohistochemistry to determine of the expression of COX-2, MMP-2, MMP9, and RANKL/RANK/OPG. ELISA assay was used to quantitate the levels of IL-1β, IL-10, TNF-α, myeloperoxidase, malondialdehyde, and glutathione. The periodontal group treated with 10 mg/kg of Atorvastatin (3.9±0.9 mm; p<0.05) showed reverse the alveolar bone loss caused Experimental Periodontal Disease compared to (L) (7.02±0.17 mm). The periodontal group treated with 10 mg/kg of Atorvastatin showed a significant reduction in MPO and MDA (p<0.05) compared to ligature only group (L). Similarly in this group, the levels of the proinflammatory cytokines IL-1β and TNF-α were significantly decreased (p<0.05). Furthermore, MMP-2, MMP-9, RANKL/RANK, and COX-2 were all downregulated by Atorvastatin treatment, while OPG expression was increased. The findings support a role of Atorvastatin for reducing the bone loss, inflammatory response, oxidative stress, and expression of extracellular matrix proteins, while reducing RANK/RANKL and increase OPG in periodontal disease.pt_BR
dc.identifier.citationARAUJO JÚNIOR, Raimundo Fernandes et al . Atorvastatin Decreases Bone Loss, Inflammation and Oxidative Stress in Experimental Periodontitis. Plos One , v. 8, n. 10, p. e75322, 2013.pt_BR
dc.identifier.doi10.1371/journal.pone.0075322
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23806
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAtorvastatina cálcicapt_BR
dc.subjectAbscesso periapicalpt_BR
dc.titleAtorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitispt_BR
dc.typearticlept_BR

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