Avaliação morfológica do pulmão em ratos diabéticos tratados com s-metilcisteína

Abstract

Introduction: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia caused by the deficiency of insulin production by the pancreas and / or in its action, leanding to long-term complications. S-methylcysteine ​​(SMC) has been investigated due to the positive effects on DM attributed to the anti-diabetic, antioxidant and anti-inflammatory functions. Objective: To evaluate the morphological changes in the lungs of rats treated with S-methylcysteine. Methodology: To achieve the objectives, we used 26 Wistar rats to induce experimental DM using streptozotocin (STZ) (50 mg / kg via i.p.) and divided into CT groups: control group; DM (blood glucose ≥ 250 mg / dL): group of diabetic rats induced by STZ and DMSM (blood glucose ≥ 250 mg / dL): group of diabetic rats induced by STZ treated with S-methylcysteine. S-methylcysteine ​​(200mg / kg) was administered by gavage daily for 30 consecutive days one week after the induction of DM (CEUA-UFRN N.012.018 / 2017). The variables analyzed included metabolic, morphological and morphometric parameters of the lung. Results: The polydipsia and polyphagia observed in diabetic animals were partially reduced in animals treated with SMC. The fasting blood glucose level was significantly lower in animals treated with S-methylcysteine, when compared to diabetic animals. As for morphology, it can be observed that diabetic animals showed loss of pulmonary architecture, increased thickness of alveolar septa, reduced respiratory area and fibrosis, and after treatment with S-methylcysteine ​​there was an improvement in these morphological changes of the lung caused by STZ . Conclusion: The results showed that treatment with S-methylcysteine ​​had positive effects on lung tissue morphology, blood glucose and some clinical parameters of experimental DM. These results suggest that SMC has a protective effect on STZ-induced diabetes mellitus.