Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumor

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dc.contributor.authorBarbosa, Carlos Augusto Galvão
dc.contributor.authorPinto, Leão Pereira
dc.contributor.authorFreitas, Roseana de Almeida
dc.contributor.authorCosta, Antonio de Lisboa Lopes
dc.contributor.authorSouza, Lélia Batista de
dc.date.accessioned2017-09-15T14:03:23Z
dc.date.available2017-09-15T14:03:23Z
dc.date.issued2005
dc.description.resumoIn this study, proliferating cell nuclear antigen (PCNA) and p53 protein expressions were analyzed in 16 cases of ameloblastoma and 8 cases of adenomatoid odontogenic tumor (AOT). The cases of ameloblastoma consisted of solid type tumors and histologic arrangements of different subtypes were observed. In some specimens, more than one histologic subtype was identified in the same lesion, and each tumor was categorized according to the predominant cell pattern. The odontogenic tumors were grouped as follows: follicular ameloblastoma (n=7), plexiform ameloblastoma (n=4), acanthomatous + follicular ameloblastoma (n=3), basal cell ameloblastoma (n=2), adenomatoid odontogenic tumor (n=8). PCNA immunohistochemical expression revealed stronger quantitative labeling index for the follicular ameloblastoma, while for p53 protein the strongest quantitative labeling index was detected in the plexiform type. Nevertheless, statistical analysis using ANOVA and Tukey's test did not detect significant differences (p>0.05) among the histologic subtypes of ameloblastoma. The findings of this study suggest that the different histologic patterns of ameloblastoma did not show a direct correlation with their clinical behavior and consequently with the prognosis of the cases. The results also indicated that the ameloblastoma has greater proliferative potential than the AOT, which can contribute to explain its more aggressive and invasive characteristics.pt_BR
dc.identifier.citationBARBOSA, Carlos Augusto Galvão et al. Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumor. Brazilian Dental Journal, v. 16, n. 1, p. 56-61, 2005.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0103-64402005000100010
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23900
dc.languageengpt_BR
dc.publisherSCIELOpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAmeloblastomapt_BR
dc.subjectAdenomatoid odontogenic tumorpt_BR
dc.subjectPCNApt_BR
dc.subjectp53 proteinpt_BR
dc.titleProliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid odontogenic tumorpt_BR
dc.typearticlept_BR

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