CCET - DEST - Artigos publicados em periódicos
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Artigo Arquitetura da informação e usabilidade: análise do processo de cadastro de autor e submissão de um artigo no periódico eletrônico bibliocanto da UFRN(Universidade Federal do Rio Grande do Norte, 2015) Maia, Maria Aniolly Queiroz; Santa Rosa, José Guilherme; Pinho, Andre Luis Santos de; Carvalho, Caio Vitoriano de Nunes e; Gusmão, Eduardo Henrique Olímpio de; Sales Júnior, Francisco Monteiro de; Fonseca Júnior, José Nivaldo; 0000-0003-4485-1774Este trabalho discorre sobre o processo de cadastro de autor e submissão de um artigo no periódico BiblioCanto, no Portal de Periódicos Eletrônicos da Universidade Federal do Rio Grande do Norte. A pesquisa com grupo de bibliotecários da UFRN envolveu análise contextual e entrevista em que foram avaliadas a arquitetura da informação e a usabilidade do periódico. Com os dados, foi possível identificar diversas falhas de design nos formulários de cadastro de autor e submissão de artigo neste Periódico. Com base nas informações obtidas, foram propostas melhorias, refinando o design e a arquitetura da informação do periódico.Artigo Usabilidade do processo de cadastro de autor no Open Journal System: análise a partir da avaliação cooperativa(Universidade Federal da Paraiba, 2017) Maia, Maria Aniolly Queiroz; Rosa, José Guilherme Santa; Pinho, André Luis Santos de; 0000-0003-4485-1774As revistas científicas eletrônicas correspondem a canais de publicação e divulgação da informação científica. Por meio delas, os usuários podem disseminar seus estudos, assim como desenvolver novas pesquisas. Um dos sistemas utilizados para criação e gestão de periódicos eletrônicos é o Open Journal Systems (OJS), utilizado na construção de portais de periódicos, assim como na criação de revistas isoladamente. Nesse sentido, acredita-se que os sistemas de gestão e criação de revistas científicas eletrônicas devem ser desenvolvidos (interna e externamente) de acordo com as necessidades dos seus usuários. No caso do desenvolvimento interno, um desses processos se refere ao cadastro de autor, por sua vez, é uma tarefa relevante no processo editorial. Assim, o estudo proposto, de temática Usabilidade de periódicos científicos, objetiva analisar a usabilidade do processo de cadastro de autor no OJS por meio da revista BiblioCanto, que integra o Portal de Periódicos Eletrônicos da Universidade Federal do Rio Grande do Norte. Para a efetivação da pesquisa, foi utilizada a técnica de Avaliação Cooperativa com um total de vinte participantes em quatro categorias: discentes de graduação, discentes de pós-graduação, docentes e bibliotecários. Os resultados apontaram que o processo analisado necessita de melhorias tais como: sinalização do ambiente de realização de cadastro; descrição e exclusão de informações solicitadas no formulário para cadastramento. Por fim, acredita-se, que de uma forma geral, o OJS atende parcialmente às necessidades dos seus usuários no tocante à usabilidade do referido softwareArtigo Ferramenta de suporte ao projeto de capas de livros a partir de princípios da ergonomia(Universidade Federal do Rio Grande do Norte, 2015) Maia, Maria Aniolly Queiroz; Sales Júnior, Francisco Monteiro de; Andruchak, Marcos Alberto; Pinho, André Luis Santos de; Rosa, José Guilherme Santa; 0000-0003-4485-1774O objetivo do trabalho foi o de construir um instrumento de suporte ao projeto de capas de livros. Buscou-se conhecer como os componentes linguísticos estão ordenados e combinados entre si, e se a relação entre eles proporciona facilidade de leitura e interpretação, comunicando informações inerentes à literatura. A ferramenta foi concebida a partir de diretrizes e conceitos do design da informação e da linguagem gráfica e visual, consolidados em 32 critérios. Para o processo de teste e validação foram avaliadas capas de livros presentes na ementa da componente curricular Ergonomia Informacional do programa de pós-graduação em Design da Universidade Federal do Rio Grande do Norte. Os resultados preliminares apontam que os critérios ‘tamanho’, ‘variação de gênero’ e ‘tipos’ são sempre observados, enquanto os critérios da categoria ‘semântica do texto e imagem’ raramente o são. O instrumento poderá ser utilizado como suporte no projeto de novas interfaces de livrosArtigo An alternative model for on-line quality monitoring for variables(International Journal of Production Economics, 2007) Ho, Linda Lee; Medeiros, Pledson Guedes de; Borges, WagnerAn alternative model for an on-line monitoring process for variables is presented in this paper. The characteristic of interest follows a normal distribution and changes of the distribution parameters are described by a two-state Markov chain. Items are produced independently and a single item is examined at every m manufactured items similar to an on-line quality procedure to monitor process for variables previously presented by Taguchi et al. [1989. Quality Engineering in Production Systems. McGraw-Hill, New York]. The objective of this study is to determine the optimal sampling interval m and the optimal control limit d that minimizes the expected cost function. A program using S-PLUS was developed to compare Taguchi’s and the alternative proposal. The alternative model provides a better performance than Taguchi’s, since it yields a lower cost and feasible parameters (control limits and sampling interval).Artigo A combined npx X control chart to monitor the process mean in a two-stage sampling(Quality and Reliability Engineering International, 2013-06) Sampaio, Elvis S.; Ho, Linda Lee; Medeiros, Pledson G. deThis paper proposes a new combined npx X control chart for monitoring the mean of a process. A sample of size n is split into two sub-samples of sizes n1 and n2 =n-n1, determined by an optimization search. The units of the first sub-sample are evaluated by attributes and plotted on an npx control chart. If this chart signals an out-of-control condition, then values of the quality characteristic of interest are collected from the units of the second sub-sample, and the sample mean is calculated and plotted on an X control chart. If both control charts signal, then the process is halted for adjustment. The possibility that all n items will not be inspected may lead to a reduction in both the cost and time spent on examining the sampled items. The performance of the proposed procedure is compared to that of two separate X and npx control charts. The proposed procedure exhibits superior performance to the X control chart for a variety of sample sizes, n, and shifts, d, of the target mean. The average time to signal (ATS) for the combined control chart was lower than that calculated for a single X or npx control chart, indicating that the combined control chart is an efficient tool for monitoring the process mean.Artigo Economical control chart with supplementary rules to monitor the average number of defects(The International Journal of Advanced Manufacturing Technology volume, 2015) Rocha, André Luiz Sena da; Medeiros, Pledson Guedes de; Ho, Linda LeeThis study proposes a procedure for an on-line process control system to monitor the average number of defects using a Shewhart-like chart with two sets of limits (viz., control and warning limits). After the production of m units, the mth item is inspected. If the number of defects exceeds the upper control limit or if, in a sequence of the last h inspections, all inspected items exhibit a number of defects between the warning and control limits, then the process is stopped for adjustment; otherwise, production continues. The properties of an ergodic Markov chain are used to obtain an expression for the average cost per item produced. The inspection interval (m), warning and control limits (W and C, respectively), and the sequence size (h) are determined by minimizing the average cost per produced item. A numerical example illustrates the proposed procedure.Artigo Seasonal variation of potential flavivirus vectors in an urban biological reserve in northeastern Brazil(Journal of Medical Entomology, 2009-11) Medeiros, Arlinete S.; Marcondes, Carlos B.; Azevedo, Paulo R. M. de; Jerônimo, Selma M. R.; Silva, Virginia P. Macedo e; Ximenes, Maria de Fátima Freire de MeloAlthough yellow fever (YF) has not been reported on the eastern coast of Brazil since 1942, there was a reemergence of dengue fever in Brazil in 1987 due to the reintroduction of Aedes aegypti (L.). To assess areas of potential risk for transmission of vector-borne diseases, a surveillance system was placed in a large Atlantic Forest reserve in Natal, Rio Grande do Norte, Brazil, where in 2004 unexplained epizootics were reported among marmosets. The etiologic agent causing the mortality in marmosets has not been identiÞed. Wyeomyia bourrouli Lutz, Haemagogus leucocelaenus Dyar & Shannon, Ae. aegypti, Aedes albopictus (Skuse), Ochlerotatus scapularis Rondani, Ochlerotatus serratus Theobald, Ochlerotatus taeniorhynchus Wiedemann, Culex quinquefasciatus Say, and Limatus durhami Theobald were collected in the park and in the proximity of the households adjacent to the park. Seasonal abundance ßuctuation was signiÞcant for Ae. aegypti, Ae. albopictus, Ochlerotatus scapularis (Rondani), and Hg. leucocelaenus. Eggs of Ae. aegypti, Ae. albopictus, and Hg. leucocelaenus were more frequently found at the conclusion of the rainy season. A signiÞcant negative correlation between the number of Ae. albopictus collected and temperature was observed (r 0.50), i.e., for each 1 C increase in temperature, the number of specimens collected decreased eight-fold. The Þndings reported herein reinforce the need for a sustainable arboviral surveillance program in this area to decrease the potential risk of emergence of vector borne diseases as YF.Artigo Prevalence of human papillomavirus in archival samples obtained from patients with cervical pre-malignant and malignant lesions from Northeast Brazil(BMC Research Notes, 2010-04) Fernandes, José V.; Meissner, Rosely V.; Carvalho, Maria G. F; Fernandes, Thales A. A. M.; Azevedo, Paulo R. M.; Sobrinho, João S.; Prado, José C. M.; Villa, Luisa L.Background: Human Papillomavirus (HPV) is considered as a necessary, but not sufficient, cause of cervical cancer. In this study, we aimed to assess the prevalence of HPV in a series of pre-malignant and malignant cervical lesion cases, to identify the virus genotypes, and to assess their distribution pattern according to lesion type, age range, and other considered variables. The samples were submitted to histopathological revision examination and analysed by polymerase chain reaction (PCR) for the presence of HPV DNA, followed by HPV typing by dot blot hybridisation. Findings: Of the analysed samples, 53.7% showed pre-malignant cervical lesions, and 46.3% presented with cervical cancer. Most cancer samples (84.1%) were classified as invasive carcinoma. The mean age of these cancer patients was 47.3 years. The overall HPV prevalence was 82.4% in patients with pre-malignant lesions and 92.0% in the cancer patients. HPV 16 was the most prevalent type, followed by HPV 18 and 58, including both single and double infections. Double infection was detected in 11.6% of the samples, and the most common combination was HPV 16+18. Conclusions: Cervical cancer appears to occur in women in a lower age range in the studied area, compared to the situation in other Brazilian regions. Furthermore, among the patients with CIN 3 and those with cancer, we observed a higher proportion of married women, women with more than one sexual partner, smokers, and individuals with less than an elementary education, relative to their counterparts. Findings: The overall HPV prevalence was 82.4% in patients with pre-malignant lesions and 92.0% in the cervical cancer patients from Northeast Brazil. HPV 16 was the most prevalent type, followed by HPV 18 and 58. The most common double infection was HPV 16+18. Cervical cancer appears to occur in women in a lower age range in the Northeast Brazil. Among the patients with CIN 3 and those with cancer, we observed a higher proportion of married women, women with more than one sexual partner, smokers, and individuals with less than an elementary education, relative to their counterparts.Artigo Seroepidemiology of Trypanosoma cruzi infection in the semiarid rural zone of the State of Rio Grande do Norte, Brazil(Revista da Sociedade Brasileira de Medicina Tropical, 2012-05) Brito, Carlos Ramon do Nascimento; Sampaio, George Harisson Felinto; Câmara, Antonia Cláudia Jácome da; Nunes, Daniela Ferreira; Azevedo, Paulo Roberto Medeiros de; Chiari, Egler; Galvão, Lúcia Maria da CunhaA seroepidemiological survey was carried out to evaluate Trypanosoma cruzi infection in an endemic area of the State of Rio Grande do Norte, Brazil, involving rural residents. Methods: Sixteen municipalities were randomly selected, 15 from the west mesoregion and one from the central, with an estimated population of 83,852 individuals. A total of 1,950 blood samples were collected in the west mesoregion and 390 in Caicó. Anti-T. cruzi antibodies were detected using the Chagatest® ELISA HAI-hemagglutination kits and indirect immunofluorescence. As sera presented indeterminate results, TESAcruzi® western blot was performed to confirm reactivity. Results: An estimated seroprevalence of 6.5% was determined for the west mesoregion and 3.3% for Caicó. Seropositivity rises progressively with the age of individuals, up to 40 years in Caicó and up to 50 years in the west mesoregion. Only educational level and knowledge regarding the triatomine were associated with seropositivity. No seroreactive individuals under 18 years of age were identified. Conclusions: Infection by T. cruzi remains high and is concentrated in municipalities in the central western area of the west mesoregion; however, evidence suggests a decline in vector transmission in this mesoregion and in Caicó. Epidemiological variables appear not to influence seropositivity, with the exception of education and knowledge concerning the triatomine, among seroreactive individuals from the west mesoregion.Artigo Prevalence of human papillomavirus type 58 in women with or without cervical lesions in northeast Brazil(Annals of Medical and Health Sciences Research, 2013-12) Fernandes, J. V.; Carvalho, M. G. F.; de Fernandes, T. A. A. M.; Araújo, J. M. G.; Azevedo, P. R. M.; Azevedo, J. C. V.; Meissner, R. VBackground: Human papillomavirus (HPV) has been recognized as a necessary, but not sufficient, cause of cervical cancer. Aim: In this study, we investigated the prevalence of HPV and the genotype distribution in women from Natal, North‑East Brazil, with normal cytology and with cervical lesions of different degrees. Subjects and Methods: Included in this study were 110 women with a normal cytology and 315 with a previous history of cervical cytological abnormalities. The patients were enrolled between January 2005 and December 2008. The cytopathological analyzes were performed by the Pap smear exam, and the pre‑malignant and maligant lesions were confirmed based on the histopathological analysis. The presence of HPV was detected by polymerase chain reaction with genotyping by dot blot hybridization. All the data were included in a database, using the software SPSS, Version 10.0 (Chicago Il, USA). Results: Overall HPV prevalence was 65.2% (277/425), with 85.9% (238/277) single and 14.1% (39/277) multiple infection. The most prevalent HPV types were HPVs 16, 58, 18, 31, and 45. HPV 16 was the most prevalent genotype, independently of the health status of patients. HPV 58 was the second most prevalent type in women with normal cytology and in those who had mild or moderate dysplasia. HPV 58 presented equal prevalence to HPV 18 in patients with severe dysplasia. However, it was less prevalent than HPV 18 in women with cervical cancer. Conclusions: The results show a high prevalence of HPV 58, especially in women with mild and moderate dysplasia, revealing the high‑frequency circulation of this genotype of HPV in the local population. This finding suggests the need to include this genotype in future HPV vaccines targeting women in this region.Artigo Prevalence of HPV infection by cervical cytologic status in Brazil(International Journal of Gynecology and Obstetrics, 2009) Fernandes, José Veríssimo; Meissner, Rosely de Vasconcellos; Carvalho, Maria Goretti Freire de; Fernandes, Thales Allyrio Araújo de Medeiros; Azevedo, Paulo Roberto Medeiros de; Villa, Luisa LinaObjectives: To assess the prevalence of human papillomavirus (HPV) infection according to cervical cytologic status in northeastern Brazil; identify other risk factors for low- and high-grade squamous intraepithelial lesions (LSILs and HSILs); and identify the most prevalent HPV genotypes associated with the lesions. Method: Two cervical smears were collected from 250 women referred for cancer screening, one for cytologic examination and the other to test for the presence of HPV by PCR with genotyping by dot blot hybridization. Result: There were 110 healthy cervices, 82 LSILs, and 58 HSILs. The overall HPV prevalence was 48%, with higher rates for HSILs, and HPV-16 was the most prevalent type. Age, multiple sexual partners, type of HPV present, smoking, and early onset of sexual activity were risk factors for cervical lesions. Conclusion: Age, multiple sexual partners, and infection with HPV-16 increased the risk of having LSILs or HSILs. Early onset of sexual activity and smoking only increased the risk of having HSILs.Artigo Controle on-line da taxa média de defeitos por item produzido numa produção finita(Production, 2014-02) Teixeira, Carla Simone de Lima; Medeiros, Pledson Guedes de; Ho, Linda LeeEste trabalho propõe uma abordagem para monitoramento da taxa média de defeitos por item produzido numa produção finita ou encomenda de N itens. A cada ciclo de m itens produzidos, inspecionam-se os últimos r itens. Em cada item inspecionado conta-se o número de defeitos e cada item é classificado como aprovado se o número de defeitos satisfizer o critério do limite de controle. Se todos os r itens forem aprovados, a produção continua, caso contrário interrompe-se a produção à procura de causas especiais. Os itens inspecionados são descartados somente quando há parada no processo. Após a produção de N itens, um lote adicional será produzido para completar a quantia encomendada, mas esses não passarão por inspeção. Será utilizada uma cadeia de Markov finita de estados discretos para determinar as probabilidades de mudança de estado. Elas são utilizadas nas expressões de custo para determinar a estratégia ótima de monitoração, que será obtida através da otimização de três parâmetros: intervalo amostral (m), tamanho da amostra retrospectiva (r) e o limite de controle (LC). Os parâmetros serão obtidos através de busca direta, de forma que se minimize a expressão do custo médio por item produzido. Um exemplo numérico ilustra a proposta.Artigo Prevalência de transtornos mentais comuns e avaliação da qualidade de vida no climatério(Revista da Associação Médica Brasileira, 2007-07) Galvão, Lílian Lira Lisboa Fagundes; Farias, Maria Cláudia Saldanha; Azevedo, Paulo Roberto Medeiros de; Vilar, Maria José Pereira; Azevedo, George Dantas deOBJETIVO. Avaliar a prevalência de transtornos mentais comuns e a qualidade de vida (QV) relacionados à saúde em mulheres no climatério. MÉTODOS. Foram incluídas 191 mulheres (entre 45 e 65 anos) em estudo analítico transversal. Um questionário, contendo informações pessoais, hábitos/saúde e dados demográficos, foi administrado em associação a instrumentos validados para medir qualidade de vida (SF-36, Medical Outcomes Study 36-item Short-Form Health Survey) e estimar a prevalência de transtornos mentais comuns (SRQ-20, Self Reporting Questionnaire). RESULTADOS. Com a utilização do SRQ-20 e empregando ponto de corte de oito ou mais respostas afirmativas, 39,8% das mulheres foram classificadas como apresentando transtornos mentais comuns. Evidenciou-se maior prevalência de transtornos mentais comuns e piores escores de QV nas mulheres com pouca escolaridade, baixa renda familiar e que não exerciam atividades profissionais fora do domicílio. Os escores médios para todos os domínios do SF-36 foram significativamente mais baixos nas mulheres categorizadas por apresentarem transtornos mentais comuns. CONCLUSÃO. A prevalência de transtornos mentais comuns é elevada na amostra de mulheres no climatério e está associada com repercussões negativas sobre sua qualidade de vida. Fatores psicossociais exercem significativa influência, e estratégias de suporte psicológico deveriam ser instituídas no contexto das políticas de saúde voltadas para mulheres no climatério.Artigo O impacto da aposentadoria no retorno migratório ao Rio Grande do Norte e ao semiárido potiguar(Informe Gepec, 2015-06) Ojima, Ricardo; Azevedo, Paulo Roberto Medeiros; Oliveira, Herick Cidarta GomesA migração de retorno tem se destacado nos estudos da área por se tornar mais representativo nos últimos anos. O Rio Grande do Norte (RN), como um estado particular no contexto nordestino devido aos seus saldos migratórios positivos, tem cerca de 30% de seus imigrantes como retornados. Assim, com o objetivo de entender alguns processos que estão envolvidos na explicação da migração de retorno para o RN, desenvolveram-se uma análise dos dados sobre migração do Censo Demográfico 2010, valendo-se de um modelo de regressão logística, para avaliar, entre outras, o impacto da seguridade social no retorno migratório. Analisaram-se também os diferenciais relacionados ao destino desse retorno para a região semiárida. Portanto, observou-se que a aposentadoria ou pensão é a variável que melhor explica a migração de retorno no modelo logístico. Confirmando para o RN o que parte da literatura da área destaca como elementos importantes para o retorno migratório.Artigo Knowledge, attitudes and practices regarding the Pap test among women in northeastern Brazil(SciELO, 2014) Albuquerque, Carla Lorenna Ferreira de; Costa, Marla da Paschoa; Nunes, Felipe Moreira; Freitas, Roberto Wagner Junior Freire de; Azevedo, Paulo Roberto Medeiros de; Fernandes, José Veríssimo; Rego, Juciane Vaz; Barreto, Humberto MedeirosCONTEXT AND OBJECTIVE: The Papanicolaou (Pap) test has been shown to be e ective in preventing cervical cancer. However, both the national and international literature shows that Pap testing has not reached the level of coverage desired. The objective of this study was to assess women’s knowledge, attitudes and practices regarding the Pap test and to investigate whether there are any associations between these three factors and the women’s sociodemographic characteristics. DESIGN AND SETTING: Cross-sectional descriptive study conducted in Floriano, Piauí. METHODS: The study was conducted among 493 women between November 2009 and December 2010. A questionnaire with precoded questions was used, and the responses were analyzed in terms of appropriateness in relation to the Pap test. RESULTS: The degrees of adequacy of knowledge, attitudes and practices regarding the Pap test were 36.7%, 67.2% and 69.6%, respectively. Among the main barriers against testing, absence of symptoms and a sense of embarrassment were the most notable. CONCLUSIONS: Women who visit doctors periodically had the most appropriate practices regarding the Pap test, but their knowledge of the procedure was poor. This suggests that these women were not receiving adequate information about the bene ts of periodic testing.Artigo Knowledge about HPV and screening of cervical cancer among women from the metropolitan region of Natal, Brazil(Hindawi Publishing Corporation, 2013-03) Lima, Érika Galvão; Lima, Diego Breno Soares de; Miranda, Cleine Aglacy Nunes; Pereira, Valeska Santana de Sena; Azevedo, Jenner Chrystian Veríssimo de; Araújo, Josélio Maria Galvão de; Fernandes, Thales Allyrio Araújo de Medeiros; Azevedo, Paulo Roberto Medeiros de; Fernandes, José VeríssimoObjective. The purpose of this study was to assess the knowledge level about HPV and screening of cervical cancer in women from the metropolitan region of Natal, Brazil. Materials and Methods. A descriptive cross-sectional study involving sexually active women was conducted.Theparticipants were submitted to a face-to-face interview, using a structured questionnaire that permitted the quantification of data and opinions of the respondents. Results.Most participants (70.9%) had poor knowledge about HPV and also the Pap test (53.0%). The high level of knowledge about HPV was associated with age, education, marital status, household income, and pregnancy, while the high level of knowledge about the Pap test proved to be associated only with education and household income. Conclusion.The results highlight the need for performing educational campaigns emphasizing the role of HPV in the etiology of cervical lesions of different degrees, including cervical cancer, as well as the importance of having a Pap test regularly to prevent these diseases.Artigo Insect vectors and their relationship with sustainable development indicators in neighborhoods of Natal, northeastern Brazil(Gaia Scientia, 2016-09) Araujo, Paulo Sérgio Fagundes; Souto, Maria Cristiana da Silva; Azevedo, Paulo Roberto Medeiros de; Ximenes, Maria de Fatima Freire de MeloThis study aimed to correlate sustainable development indicators with the occurrence of mosquitoes from the genus Aedes and phlebotominae sand flies, vectors of dengue fever, American visceral leishmaniasis and American tegumentary leishmaniasis, in order to establish a relationship between infestation indices and sustainability conditions in southern and northern neighborhoods of Natal, Brazil, adjacent to environmental protection zones 5 and 9, respectively. Data were obtained on Aedes aegypti and A. albopictus breeding sites and captures of phlebotominae sand flies of the genus Lutzomyia in the study area between 2006 and 2008, from the Center of Zoonosis Control of the Municipal Health Secretariat, and correlated with environmental and social indicators. Factorial analysis was applied to transform these indicators into a sustainability index for each neighborhood studied (Neighborhood Sustainability Index – NSI). Relating these indices with the occurrence of insect vectors at these sites shows a high positive correlation between SID and the Breteau index of A. aegypti (p=0.028) and with the index of household infestation by phlebotominae sand flies (p=0.01). This reveals a pattern allowing the association of sustainability conditions in the study areas with the occurrence of these insects. Analyses demonstrate the occurrence of a larger number of A. aegypti breeding sites and higher indices of household infestation by phlebotominae sand flies in neighborhoods with lower sustainability indices. Knowledge of the relationship between sustainable development indicators and the occurrence of zoonotic vectors may contribute to public health programs as well as to a restructuring of public policies in the study areas.Artigo Immunoexpression of transforming growth factor beta and interferon gamma in radicular and dentigerous cysts(Elsevier, 2014-09) Moraes, Maiara de; Rocha-Neto, Pedro Carlos da; Matos, Felipe Rodrigues de; Lopes, Maria Luiza Diniz de Sousa; Azevedo, Paulo Roberto Medeiros de; Costa, Antonio de Lisboa LopesIntroduction: The aim of this study was to evaluate and compare the immunohistochemical expression of transforming growing factor beta (TGF-b) and interferon gamma (IFN-g) between radicular cysts (RCs) and dentigerous cysts (DCs). Methods: Twenty RCs and DCs were selected for analysis of the immunoexpression of TGF-b and IFN-g in the epithelium and capsule. Results: The cell reactivity of TGF-b and IFN-g in the lining epithelium and capsule of RCs showed no significant differences when compared with DCs (P > .05). There was a tendency of a higher expression of TGF-b in the capsule of DCs. Conclusions: Our results showed the presence of TGF-b and IFN-g in RCs and DCs, supporting the hypothesis that both participate in the development of these lesions, where IFN-g usually plays a role in bone resorption, which is counterbalanced by the osteoprotective activity performed by TGF-b.Artigo Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazil(Molecular Medicine Reports, 2011-08) Fernandes, José Verissímo; Meissner, Rosely de Vasconcellos; Carvalho, Maria Goretti F.; Fernandes, Thales A. A. de Medeiros; Azevedo, Paulo Roberto Medeiros; Azevedo, Judson Weber Verissímo de; Araújo, Josélio Maria G. deThis study analyzed the prevalence of human papillomavirus (HPV) in cervical specimens obtained from women with normal cytology and with cervical cancer, in order to evaluate their correlation with health status and demographic characteristics, as well as sexual and reproductive activity in women treated at a cancer reference hospital in Natal, Northeast Brazil. A total of 158 women were divided into 2 groups according to their health status: group I comprised 110 women with normal cytology, and group II comprised 48 women with cervical cancer. Cervical smears were analyzed by cytological or histopathological examination for the detection of cytological alterations, and by PCR for HPV DNA detection using MY09/11 primers, followed by HPV genotyping by dot blot hybridization. Results showed overall HPV prevalence to be 24.5% in group I, with 19.1% of patients having single infection and 5.4% double infection. The HPV prevalence in group II was 85.4%, with 79.2% of patients having single and 6.2% double infection. We identified 10 different HPV genotypes, most with high oncogenic potential. HPV 16 was the most prevalent genotype in the two studied groups, followed by HPV 58 and HPV 18. High-risk HPV genital infection, chronological age, ethnicity, early onset of sexual and reproductive activities, multiple sexual partners and smoking increased the risk for cervical cancer.Artigo Choosing between Cox proportional hazards and logistic models for interval-censored data via bootstrap(Journal of Applied Statistics, 2003) Corrente, José Eduardo; Chalita, Liciana V. A. S.; Moreira, Jeanete AlvesThis work develops a new methodology in order to discriminate models for interval-censored data based on bootstrap residual simulation by observing the deviance difference from one model in relation to another, according to Hinde (1992). Generally, this sort of data can generate a large number of tied observations and, in this case, survival time can be regarded as discrete. Therefore, the Cox proportional hazards model for grouped data (Prentice&Gloeckler, 1978) and the logistic model (Lawless, 1982) can be fitted by means of generalized linear models. Whitehead (1989) considered censoring to be an indicative variable with a binomial distribution and fitted the Cox proportional hazards model using complementary log-log as a link function. In addition, a logistic model can be fitted using logit as a link function. The proposed methodology arises as an alternative to the score tests developed by Colosimo et al. (2000), where such models can be obtained for discrete binary data as particular cases from the Aranda-Ordaz distribution asymmetric family. These tests are thus developed with a basis on link functions to generate such a fit. The example that motivates this study was the dataset from an experiment carried out on a flax cultivar planted on four substrata susceptible to the pathogen Fusarium oxysoprum. The response variable, which is the time until blighting, was observed in intervals during 52 days. The results were compared with the model fit and the AIC values.