Are phosphatidylcholine and lysophosphatidylcholine body levels potentially reliable biomarkers in obesity?: a review of human studies

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dc.contributor.authorReis, Bruna Zavarize
dc.contributor.authorBellot, Paula Emília Nunes Ribeiro
dc.contributor.authorMoia, Melissa Nunes
dc.contributor.authorPedrosa, Lucia Fatima Campos
dc.contributor.authorTasic, Ljubica
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorEvangelista, Karine Cavalcanti Maurício Sena
dc.date.accessioned2024-03-04T19:32:02Z
dc.date.available2024-03-04T19:32:02Z
dc.date.issued2023-01
dc.description.resumoPhosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low-density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detailpt_BR
dc.identifier.citationBELLOT, Paula Emília Nunes Ribeiro; MOIA, Melissa Nunes; REIS, Bruna Zavarize; PEDROSA, Lucia Fatima Campos; TASIC, Ljubica; BARBOSA, Fernando; EVANGELISTA, Karine Cavalcanti Maurício Sena. Are phosphatidylcholine and lysophosphatidylcholine body levels potentially reliable biomarkers in obesity?: a review of human studies. Molecular Nutrition & Food Research, [S.l.], v. 67, n. 7, p. 1-12, 27 jan. 2023. DOI: 10.1002/mnfr.202200568. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200568. Acesso em: 16 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1002/mnfr.202200568
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57743
dc.languageenpt_BR
dc.publisherMolecular Nutrition & Food Researchpt_BR
dc.subjectPhosphatidylcholinept_BR
dc.subjectLysophosphatidylcholinept_BR
dc.subjectObesitypt_BR
dc.subjectBiomarkerspt_BR
dc.titleAre phosphatidylcholine and lysophosphatidylcholine body levels potentially reliable biomarkers in obesity?: a review of human studiespt_BR
dc.typearticlept_BR

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