Association between C-reactive protein and physical performance in older populations: results from the International Mobility In Aging Study (IMIAS)

Sousa, Ana Carolina Patrício Albuquerque; Zunzunegui, Maria-Victoria; Li, Annie; Phillips, Susan P.; Guralnik, Jack M.; Guerra, Ricardo Oliveira

Association between C-reactive protein and physical performance in older populations: results from the International Mobility In Aging Study (IMIAS)

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dc.contributor.author	Sousa, Ana Carolina Patrício Albuquerque
dc.contributor.author	Zunzunegui, Maria-Victoria
dc.contributor.author	Li, Annie
dc.contributor.author	Phillips, Susan P.
dc.contributor.author	Guralnik, Jack M.
dc.contributor.author	Guerra, Ricardo Oliveira
dc.date.accessioned	2021-01-05T15:04:56Z
dc.date.available	2021-01-05T15:04:56Z
dc.date.issued	2016-01-28
dc.description.resumo	Background and objective: C-reactive protein (CRP) is a widely used cardiovascular risk marker, but questions remain about its role in the disability process in old age. This study examines the associations between CRP levels and physical performance in old age in different societies. Methods: data were collected during the baseline survey of IMIAS in 2012 in Kingston (Canada), Saint-Hyacinthe (Canada), Manizales (Colombia) and Natal (Brazil). Approximately 200 men and 200 women aged 65–74 were recruited at each site. CRP was assessed using a high sensitivity assay and categorised as low (<1 mg/l), moderate (1–3 mg/l), high (3–10 mg/l) and very high (≥10 mg/l). Participants were interviewed at home; blood pressure, weight and height were measured. Physical function was assessed with the Short Physical Performance Battery (SPPB) and hand grip strength. Data were analysed using descriptive statistics, bivariate analysis (χ²) and linear or logistic regression. Results: CRP was significantly associated with low hand grip strength and poor physical performance in bivariate analyses. Hand grip strength association with CRP disappeared after adjustment by socioeconomic factors and health behaviours. The odds of poor physical function was OR = 2.67 [95% CI 1.43–4.99] comparing the highest and lowest CRP categories after adjustment by relevant covariates. The three SPPB components were assessed separately. Graded associations between low CRP and faster gait speed and shorter time to rise from a chair were observed in adjusted models. Association between impaired balance and CRP was attenuated after adjustment by relevant covariates, OR = 1.15 [0.65–2.04]. Conclusions: CRP could be a possible pathway from inflammation to physical decline in older populations	pt_BR
dc.identifier.citation	SOUSA, Ana Carolina Patrício Albuquerque; ZUNZUNEGUI, Maria-Victoria; LI, Annie; PHILLIPS, Susan P.; GURALNIK, Jack M.; GUERRA, Ricardo Oliveira. Association between C-reactive protein and physical performance in older populations: results from the International Mobility In Aging Study (IMIAS). Age And Ageing, [s. l.], v. 45, n. 2, p. 274-280, 28 jan. 2016. Oxford University Press (OUP). Disponível em: https://academic.oup.com/ageing/article/45/2/274/2195345. Acesso em: 18 ago. 2020. http://dx.doi.org/10.1093/ageing/afv202.	pt_BR
dc.identifier.doi	10.1093/ageing/afv202
dc.identifier.issn	1468-2834 (online)
dc.identifier.issn	0002-0729 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31183
dc.language	en	pt_BR
dc.publisher	Oxford University Press (OUP)	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Inflammation	pt_BR
dc.subject	Physical function	pt_BR
dc.subject	Muscle strength	pt_BR
dc.subject	Ageing	pt_BR
dc.subject	Older people	pt_BR
dc.title	Association between C-reactive protein and physical performance in older populations: results from the International Mobility In Aging Study (IMIAS)	pt_BR
dc.type	article	pt_BR