Minocycline treatment reduces white matter damage after excitotoxic striatal injury

Guimarães, Joanilson S.; Freire, Marco Aurelio M.; Lima, Rafael R.; Picanço-Diniz, Cristovam W.; Pereira, Antonio; Gomes-Leal, Walace

Minocycline treatment reduces white matter damage after excitotoxic striatal injury

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dc.contributor.author	Guimarães, Joanilson S.
dc.contributor.author	Freire, Marco Aurelio M.
dc.contributor.author	Lima, Rafael R.
dc.contributor.author	Picanço-Diniz, Cristovam W.
dc.contributor.author	Pereira, Antonio
dc.contributor.author	Gomes-Leal, Walace
dc.date.accessioned	2017-05-26T15:00:54Z
dc.date.available	2017-05-26T15:00:54Z
dc.date.issued	2010
dc.description.resumo	We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-D-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/ macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1+ cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after postlesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/ macrophage activation contributes to this pathological phenomenon.	pt_BR
dc.identifier.issn	0006-8993
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23119
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Excitotoxicity	pt_BR
dc.subject	Neurodegeneration	pt_BR
dc.subject	Oligodendrocyte	pt_BR
dc.subject	Myelin	pt_BR
dc.subject	White matter	pt_BR
dc.subject	Striatum	pt_BR
dc.title	Minocycline treatment reduces white matter damage after excitotoxic striatal injury	pt_BR
dc.type	article	pt_BR