Characterizing speed cells in the rat hippocampus

Góis, Zé Henrique T. D.; Tort, Adriano Bretanha Lopes

Characterizing speed cells in the rat hippocampus

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dc.contributor.author	Góis, Zé Henrique T. D.
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.date.accessioned	2019-01-07T16:28:30Z
dc.date.available	2019-01-07T16:28:30Z
dc.date.issued	2018-11-13
dc.description.resumo	Spatial navigation relies on visual landmarks as well as on self-motion information. In familiar environments, both place and grid cells maintain their firing fields in darkness, suggesting that they continuously receive information about locomotion speed required for path integration. Consistently, "speed cells" have been previously identified in the hippocampal formation and characterized in detail in the medial entorhinal cortex. Here we investigated speed-correlated firing in the hippocampus. We show that CA1 has speed cells that are stable across contexts, position in space, and time. Moreover, their speed-correlated firing occurs within theta cycles, independently of theta frequency. Interestingly, a physiological classification of cell types reveals that all CA1 speed cells are inhibitory. In fact, while speed modulates pyramidal cell activity, only the firing rate of interneurons can accurately predict locomotion speed on a sub-second timescale. These findings shed light on network models of navigation.	pt_BR
dc.identifier.citation	GÓIS, Z. H. T. D.; TORT, A. B. L. Characterizing Speed Cells in the Rat Hippocampus. [S. l.], Cell Reports, n. 25, v. 7, p. 1872–1884. doi: 10.1016/j.celrep.2018.10.054	pt_BR
dc.identifier.doi	10.1016/j.celrep.2018.10.054.
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/26422
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	CA1	pt_BR
dc.subject	hippocampus	pt_BR
dc.subject	neuronal coding	pt_BR
dc.subject	path integration	pt_BR
dc.subject	place cells	pt_BR
dc.subject	rate coding	pt_BR
dc.subject	spatial navigation	pt_BR
dc.subject	speed cells	pt_BR
dc.subject	theta	pt_BR
dc.title	Characterizing speed cells in the rat hippocampus	pt_BR
dc.type	article	pt_BR