Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts

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dc.contributor.authorMoraes, Maiara de
dc.contributor.authorLucena, Hévio Freitas de
dc.contributor.authorAzevedo, Paulo Roberto Medeiros de
dc.contributor.authorQueiroz, Lélia Maria Guedes
dc.contributor.authorCosta, Antonio de Lisboa Lopes
dc.date.accessioned2023-01-16T20:34:04Z
dc.date.available2023-01-16T20:34:04Z
dc.date.issued2011-05
dc.description.resumoObjective: Receptor activator of nuclear factor-kB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumour necrosis factor family involved in bone metabolism. The formation, differentiation and activity of osteoclasts are regulated by these proteins. To clarify the roles of osteoclast regulatory factors in cystic expansion of odontogenic cysts, expression of these proteins were analysed in radicular and dentigerous cysts. Design: The immunohistochemistry expression of these biomarkers were evaluated and measured in lining epithelium and fibrous capsule of the radicular (n = 20) and dentigerous cysts (n = 20). Results: A similar expression in lining epithelium was observed in the lesions. The fibrous capsule of dentigerous cyst showed a higher content of RANK-positive and RANKL-positive cells than fibrous capsule of radicular cyst. In the lining epithelium the RANKL/OPG ratio showed higher numbers of OPG-positive than RANKL-positive cells, whereas fibrous capsule of the cysts had a tendency to present a similar expression (OPG = RANKL). Conclusion: Ours findings indicate the presence of RANK, RANKL and OPG in cysts. Moreover, increased expression of OPG compared to RANKL in the lining epithelium could contribute to the differential bone resorption activity in theses lesions.pt_BR
dc.identifier.citationMORAES, Mayara et al. Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts. Archives of Oral Biology, v. 56, p. 1256-1263, 2011. Disponível em: http://www.sciencedirect.com/science/article/pii/S0003996911001634. Acesso em 08 dez. 2017pt_BR
dc.identifier.doi10.1016/j.archoralbio.2011.05.009
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/50964
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectRadicular cystpt_BR
dc.subjectDentigerous cystpt_BR
dc.subjectReceptor activator of nuclearpt_BR
dc.subjectFactor-kBpt_BR
dc.subjectRANK ligand and osteoprotegerinpt_BR
dc.titleComparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cystspt_BR
dc.typearticlept_BR

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