Combination sciatic nerve graft and fibroblastic growth factor 2 promotestissue regeneration for NF-200 and 5-HT in spinal cord injury

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dc.contributor.authorFernandes, Aline Samaya Santos
dc.contributor.authorCastro, Aline Brito Ferreira de
dc.contributor.authorRêgo, Amália Cinthia Meneses do
dc.contributor.authorAraújo Filho, Irami
dc.contributor.authorLucena, Eudes Euler de Souza
dc.contributor.authorCavalcanti, José Rodolfo Lopes de Paiva
dc.contributor.authorCosta, Ianara Mendonça da
dc.contributor.authorCavalcante, Jeferson de Souza
dc.contributor.authorCosta, Mirian Stela Maris de Oliveira
dc.contributor.authorGuzen, Fausto Pierdoná
dc.date.accessioned2021-04-08T10:44:55Z
dc.date.available2021-04-08T10:44:55Z
dc.date.issued2018-07
dc.description.resumoTraumatic injury to the spinal cord results in a rapid and significant loss of function. One barrier to successful regeneration in the adult CNS is the diminished axonal growth capacity after maturation. Therefore, strategies that seek to promote the restoration of function to the chronically injured spinal cord have high therapeutic value. Neurotrophic factors and peripheral nerves are known to be good substrates for bridging the lesions associatedwith CNS trauma. The role of fibroblast growth factor-2, when added to the sciatic nerve, was examined following spinal cord injury in a rat. We evaluated whether FGF-2 added to a sciatic nerve graft placed in a gap promoted nerve recovery following a complete transection of the spinal cord and if it could enhance neuronal plasticity. Rats underwent a transection at the thoracic level, which was repaired with saline or a fragment of the sciatic nerve. In another group, FGF-2 was added immediately after thelesion. The effects of FGF-2 and the fragment of the sciatic nerve graft on neuronal plasticity were investigated at the epicenterof the injury using NF-200 and 5-HT immunoreactivity after 8 weeks.A high number of NF-200 and 5-HT immunoreactive fibers were observed in the treated groups with sciatic nerve graft in the presence or absence of FGF-2 when compared to the saline group. However, a small number of NF-200(p=0.03)and 5-HT fibers were observed in the epicenter of the graft when FGF-2 was added,when compared to the group that received sciatic nerve graft. These results indicate that sciatic nerve grafting favors the growth of fibers in the traumatized spinal cord, an effect that is slightly influenced by the addition of FGF-2 to the NF-200 and 5-HT immunoreactive fiberspt_BR
dc.identifier.citationFERNANDES, Aline Samaya Santos; CASTRO, Aline Brito Ferreira de; RÊGO, Amália Cinthia Meneses do; ARAÚJO FILHO, Irami; LUCENA, Eudes Euler de Souza; CAVALCANTI, José Rodolfo Lopes de Paiva; COSTA, Ianara Mendonça da; CAVALCANTE, Jeferson de Souza; COSTA, Mirian Stela Maris de Oliveira; GUZEN, Fausto Pierdoná. Combination sciatic nerve graft and fibroblastic growth factor 2 promotes tissue regeneration for NF-200 and 5-HT in spinal cord injury. Research Journal Of Pharmaceutical, Biological And Chemical Sciences, [s. l.], v. 4, n. 9, p. 246-254, jul. 2018. Disponível em: https://www.rjpbcs.com/2018_9.4.html. Acesso em: 20 jul. 2020.pt_BR
dc.identifier.issn0975-8585
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/32112
dc.languageenpt_BR
dc.publisherResearch Journal of Pharmaceutical, Biological and Chemical Sciencespt_BR
dc.subjectFibroblastic growth factor-2pt_BR
dc.subjectPlasticitypt_BR
dc.subjectRegenerationpt_BR
dc.subjectSciatic nerve graft and spinal cordpt_BR
dc.titleCombination sciatic nerve graft and fibroblastic growth factor 2 promotestissue regeneration for NF-200 and 5-HT in spinal cord injurypt_BR
dc.typearticlept_BR

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