Effects of exercise on the levels of BDNF and executive function in adolescents: a protocol for systematic review and meta-analysis

Azevedo, Kesley Pablo Morais de; Oliveira Segundo, Victor Hugo de; Medeiros, Gidyenne Christine Bandeira Silva de; Mata, Ádala Nayana de Sousa; García, Daniel Ángel; Leitão, José Carlos Gomes de Carvalho; Knackfuss, Maria Irany; Piuvezam, Grasiela

Effects of exercise on the levels of BDNF and executive function in adolescents: a protocol for systematic review and meta-analysis

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dc.contributor.author	Azevedo, Kesley Pablo Morais de
dc.contributor.author	Oliveira Segundo, Victor Hugo de
dc.contributor.author	Medeiros, Gidyenne Christine Bandeira Silva de
dc.contributor.author	Mata, Ádala Nayana de Sousa
dc.contributor.author	García, Daniel Ángel
dc.contributor.author	Leitão, José Carlos Gomes de Carvalho
dc.contributor.author	Knackfuss, Maria Irany
dc.contributor.author	Piuvezam, Grasiela
dc.date.accessioned	2021-01-05T13:57:46Z
dc.date.available	2021-01-05T13:57:46Z
dc.date.issued	2019-07
dc.description.resumo	Backoground: Evidence available in the literature suggests that physical exercise increases the release of brain-derived neurotrophic factor (BDNF) in humans and may possibly be related to improvements in executive function. However, studies of this phenomenon in adolescents are still scarce. The objective of this work is to describe the protocol for a systematic review (SR) and meta-analysis of interventional studies aiming to determine the effect of physical exercise on BDNF levels and executive function in adolescents. Methods: This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) and by the Cochrane Handbook of Systematic Reviews of Interventions. The databases to be searched are PubMed, EMBASE, Scopus, ScienceDirect, Web of Science, SPORTDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL. Interventional studies conducted on adolescents with different exercise protocols and evaluations of BDNF levels and executive function in pre- and post-intervention periods will be included in the systematic review. The characteristics of the studies, participants, and main results will be described, then the evaluation of the risk of biases and the level of evidence obtained by the protocol will be assessed. The selection of studies, data extraction, and evaluation of the methodological quality will be performed by 2 experienced reviewers independently. Conclusion: The systematic review will present the effects of the practice of physical exercises on the BDNF and executive function levels. The results will strengthen the interventions with the focus on the brain health of adolescents through general orientations and the evidences described shall direct future research. PROSPERO registration number: CRD42018110683 Abbreviations: BDNF = brain-derived neurotrophic factor, CPF = prefrontal cortex, GRADE = Grading of Recommendations Assessment, Development, and Evaluation, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, SR = systematic review	pt_BR
dc.identifier.citation	AZEVEDO, Kesley Pablo Morais de; OLIVEIRA SEGUNDO, Victor Hugo de; MEDEIROS, Gidyenne Christine Bandeira Silva de; MATA, Ádala Nayana de Sousa; GARCÍA, Daniel Ángel; LEITÃO, José Carlos Gomes de Carvalho; KNACKFUSS, Maria Irany; PIUVEZAM, Grasiela. Effects of exercise on the levels of BDNF and executive function in adolescents. Medicine, [s. l.], v. 98, n. 28, p. 1-5, jul. 2019. Ovid Technologies (Wolters Kluwer Health). Disponível em: https://journals.lww.com/md-journal/FullText/2019/07120/Effects_of_exercise_on_the_levels_of_BDNF_and.87.aspx. Acesso em: 21 ago. 2020. http://dx.doi.org/10.1097/md.0000000000016445.	pt_BR
dc.identifier.doi	10.1097/md.0000000000016445
dc.identifier.issn	0025-7974
dc.identifier.issn	1536-5964
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31181
dc.language	en	pt_BR
dc.publisher	Lippincott, Williams & Wilkins	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Adolescent	pt_BR
dc.subject	BDNF	pt_BR
dc.subject	Executive function	pt_BR
dc.subject	Exercise	pt_BR
dc.subject	Systematic review	pt_BR
dc.title	Effects of exercise on the levels of BDNF and executive function in adolescents: a protocol for systematic review and meta-analysis	pt_BR
dc.type	article	pt_BR