Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca

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dc.contributor.authorLeão, Richardson Naves
dc.contributor.authorTargino, Zé H.
dc.contributor.authorColom, Luis V.
dc.contributor.authorFisahn, André
dc.date.accessioned2017-05-26T18:12:23Z
dc.date.available2017-05-26T18:12:23Z
dc.date.issued2015
dc.description.resumoThe medial septum/diagonal band of Broca (MS/DBB) is crucial for hippocampal theta rhythm generation (4-12 Hz). However, the mechanisms behind theta rhythmogenesis are still under debate. The MS/DBB consists, in its majority, of three neuronal populations that use acetylcholine, GABA, or glutamate as neurotransmitter. While the firing patterns of septal neurons enable the MS/DBB to generate rhythmic output critical for the generation of the hippocampal theta rhythm, the ability to synchronize these action potentials is dependent on the interconnectivity between the three major MS/DBB neuronal populations, yet little is known about intraseptal connections. Here we assessed the connectivity between pairs of MS/DBB neurons with paired patch-clamp recordings. We found that glutamatergic and GABAergic neurons provide intraseptal connections and produce sizable currents in MS/DBB postsynaptic cells. We also analyzed linear and nonlinear relationships between the action potentials fired by pairs of neurons belonging to various MS/DBB neuronal populations. Our results show that while the synchrony index for action potential firing was significantly higher in pairs of GABAergic neurons, coherence of action potential firing in the theta range was similarly low in all pairs analyzed. Recurrence analysis demonstrated that individual action potentials were more recurrent in cholinergic neurons than in other cell types. Implementing sparse connectivity in a computer model of the MS/DBB network reproduced our experimental data. We conclude that the interplay between the intrinsic membrane properties of different MS/DBB neuronal populations and the connectivity among these populations underlie the ability of the MS/DBB network to critically contribute to hippocampal theta rhythmogenesis.pt_BR
dc.identifier.doi10.1152/jn.00367.2014
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23134
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectmedial septumpt_BR
dc.subjecttheta rhythmpt_BR
dc.subjectsynchronizationpt_BR
dc.subjectcholinergic neuronpt_BR
dc.subjectGABAergic neuronpt_BR
dc.subjectglutamatergic neuronpt_BR
dc.titleInterconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Brocapt_BR
dc.typearticlept_BR

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