Antibrush border antibody disease: a case report and literature review

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dc.contributor.authorAlmeida, Jose Bruno de
dc.contributor.authorBrito, Laíse Pereira Arcoverde Fechine
dc.contributor.authorGuedes, Felipe Leite
dc.contributor.authorVale, Pedro Henrique Cavalcante
dc.contributor.authorSantos, Rivaldo Pereira
dc.contributor.authorMartins, Sílvia Queiroz Santos
dc.contributor.authorDantas, Gleiko Yuri de Figueredo
dc.contributor.authorWanderley, David
dc.contributor.authorAraújo, Stanley de Almeida
dc.contributor.authorSilva, Gyl Eanes Barros
dc.date.accessioned2023-08-02T19:19:21Z
dc.date.available2023-08-02T19:19:21Z
dc.date.issued2021
dc.description.resumoAnti-brush border antibody (ABBA) disease, also called anti–low-density lipoprotein receptor-related protein 2 (anti-LRP2) nephropathy, occurs due to the formation of antibodies against brush border antigens of the renal proximal convoluted tubule. We report a case of ABBA disease in a male farmer in his 30s who presented with 2 years of polyuria, dysuria, nocturia, and urinary urgency. He described a history of long-term occupational exposure to pesticides and silica, evolving into possible pneumoconiosis, and prior pulmonary tuberculosis. At presentation, he had reduced kidney function (serum creatinine 3.6 mg/dL) with hyponatremia, hypokalemia, hypophosphatemia, a normal anion gap, metabolic acidosis, and respiratory acidosis, and 2.2 g/day of urine proteinuria. The kidney biopsy was consistent with ABBA, showing amorphous immune-deposits in the tubular basement membrane and strong positivity on indirect immunofluorescence in the brush border of the proximal tubules. The trigger for production of ABBA is still unknown, but it may be associated with chronic conditions such as pulmonary tuberculosis and occupational exposures such as silica and pesticides, as seen in the patient in this report. Most cases do not respond to immunosuppression, and the prognosis is poor.pt_BR
dc.identifier.citationALMEIDA, José Bruno de, et al. Antibrush Border Antibody Disease: a case report and literature review. Kidney Medicine, [S.L.], v. 3, n. 5, p. 848-855, set. 2021. Elsevier BV. http://dx.doi.org/10.1016/j.xkme.2021.04.015. Disponível em: https://www.sciencedirect.com/science/article/pii/S259005952100128X?via%3Dihub. Acesso em: 27 jul. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.xkme.2021.04.015
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54343
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectanti-brush border antibody diseasept_BR
dc.subjectauto-antibodiespt_BR
dc.subjectautoimmunitypt_BR
dc.subjectchronic kidney diseasept_BR
dc.subjectkidney biopsypt_BR
dc.subjectmegalinpt_BR
dc.titleAntibrush border antibody disease: a case report and literature reviewpt_BR
dc.typearticlept_BR

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