Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells

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dc.contributor.authorGarcia-Bennett, Alfonso E.
dc.contributor.authorKozhevnikova, Mariya
dc.contributor.authorKönig, Niclas
dc.contributor.authorZhou, Chunfang
dc.contributor.authorLeão, Richardson Naves
dc.contributor.authorKnöpfel, Thomas
dc.contributor.authorPankratova, Stanislava
dc.contributor.authorTrolle, Carl
dc.contributor.authorBerezin, Vladimir
dc.contributor.authorBock, Elisabeth
dc.contributor.authorAldskogius, Håkan
dc.contributor.authorKozlova, Elena N.
dc.date.accessioned2018-11-26T17:37:44Z
dc.date.available2018-11-26T17:37:44Z
dc.date.issued2013
dc.description.resumoStem cell transplantation holds great hope for the replacement of damaged cells in the nervous system. However, poor long-term survival after transplantation and insufficiently robust differentiation of stem cells into specialized cell types in vivo remain major obstacles for clinical application. Here, we report the development of a novel technological approach for the local delivery of exogenous trophic factor mimetics to transplanted cells using specifically designed silica nanoporous particles. We demonstrated that delivering Cintrofin and Gliafin, established peptide mimetics of the ciliary neurotrophic factor and glial cell line-derived neurotrophic factor, respectively, with these particles enabled not only robust functional differentiation of motor neurons from transplanted embryonic stem cells but also their long-term survival in vivo. We propose that the delivery of growth factors by mesoporous nanoparticles is a potentially versatile and widely applicable strategy for efficient differentiation and functional integration of stem cell derivatives upon transplantation.pt_BR
dc.identifier.citationGARCIA-BENNETT, A. E. et al. Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells. Send to Stem Cells Transl Med., v. 2, n. 11, p. 905-915, 2013. DOI: 10.5966/sctm.2013-0072pt_BR
dc.identifier.doi10.5966/sctm.2013-0072
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/26177
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCell transplantationpt_BR
dc.subjectDifferentiationpt_BR
dc.subjectEmbryonic stem cellspt_BR
dc.subjectNervous systempt_BR
dc.subjectNeural differentiationpt_BR
dc.subjectNeural stem cellpt_BR
dc.subjectStem cell culturept_BR
dc.subjectTransplantationpt_BR
dc.titleDelivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cellspt_BR
dc.typearticlept_BR

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