Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranhão

Monteiro, S. C. Moutinho; Sousa, I. H. de; Belfort, I. K. Pereira; Nunes, J. D.; Penha, B. A. Sousa; Santos, Marcelo dos; Louro, I. Drumond; Silva, I. D. C. Guerreiro da

Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranhão

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dc.contributor.author	Monteiro, S. C. Moutinho
dc.contributor.author	Sousa, I. H. de
dc.contributor.author	Belfort, I. K. Pereira
dc.contributor.author	Nunes, J. D.
dc.contributor.author	Penha, B. A. Sousa
dc.contributor.author	Santos, Marcelo dos
dc.contributor.author	Louro, I. Drumond
dc.contributor.author	Silva, I. D. C. Guerreiro da
dc.date.accessioned	2021-02-09T16:59:16Z
dc.date.available	2021-02-09T16:59:16Z
dc.date.issued	2016-02-19
dc.description.resumo	Inter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with Native American, European, and African ancestries, and is therefore considered as one of the most intermixed populations in the world. A thorough knowledge of the genetic frequencies of CYP3A4 allelic variants is useful for the establishment of better pharmacological therapies; therefore, the aim of this study was to describe the polymorphic frequencies for CYP3A4 -392A>G (rs2740574) in a sample population from Maranhão, Brazil. Our results showed that 75.1, 21.9, and 3.0% of the individuals expressed the -392AA, -392AG, and -392GG genotypes, respectively. The -392A and -392G alleles were observed in 86.1 and 13.9% of the population, respectively. Our results reiterate the need for a better understanding of the variations in the genotype and allele frequencies of CYP3A4 -392A>G polymorphisms in various Brazilian regions, in order to elucidate the variability in drug response	pt_BR
dc.identifier.citation	MONTEIRO, S. C. M. et al. Genetic variability of CYP3A4 in a heterogeneous brazilian population from Maranhão. Genetics and Molecular Research, [s. l.], v. 15, p. 1-6, fev. 2016. Disponível em: https://www.geneticsmr.com/sites/default/files/articles/year2016/vol15-1/pdf/gmr7275.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/gmr.15017275	pt_BR
dc.identifier.doi	10.4238/gmr.15017275
dc.identifier.issn	1676-5680 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31426
dc.language	en	pt_BR
dc.publisher	Fundação de Pesquisas de Ribeirão Preto	pt_BR
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/br/	*
dc.subject	CYP3A4*1B	pt_BR
dc.subject	Polymorphism	pt_BR
dc.subject	Genetic variability	pt_BR
dc.subject	Drug metabolism	pt_BR
dc.subject	Pharmacogenetics	pt_BR
dc.title	Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranhão	pt_BR
dc.type	article	pt_BR