Electrophysiological evidence that the retrosplenial cortex displays a strong and specific activation phased with hippocampal theta during paradoxical (REM) sleep

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dc.contributor.authorKoike, Bruna Del Vechio
dc.contributor.authorFarias, Kelly Soares
dc.contributor.authorBillwiller, Francesca
dc.contributor.authorAlmeida-Filho, Daniel
dc.contributor.authorLibourel, Paul-Antoine
dc.contributor.authorTiran-Cappello, Alix
dc.contributor.authorParmentier, Régis
dc.contributor.authorBlanco, Wilfredo
dc.contributor.authorRibeiro, Sidarta Tollendal Gomes
dc.contributor.authorLuppi, Pierre-Herve
dc.contributor.authorQueiroz, Claudio Marcos Teixeira de
dc.date.accessioned2017-07-31T12:11:17Z
dc.date.available2017-07-31T12:11:17Z
dc.date.issued2017-07-20
dc.description.resumoIt is widely accepted that cortical neurons are similarly more activated during waking and paradoxical sleep (PS, aka REM) than during slow wave sleep (SWS). However, we recently reported using Fos labeling that only a few limbic cortical structures including the retrosplenial (RSC) and anterior cingulate (ACA) cortices contain a large number of neurons activated during PS hypersomnia. Our aim in the present study was to record local field potentials (LFPs) and unit activity from these two structures across all vigilance states in freely moving male rats to determine whether the RSC and the ACA are electrophysiologically specifically active during basal PS episodes. We found that theta power was significantly higher during PS than during active waking (aWK) similarly in the RSC and hippocampus (HPC) but not in ACA. Phase-amplitude coupling between HPC theta and gamma oscillations strongly and specifically increased in RSC during PS compared with aWK. It did not occur in ACA. Further, 68% and 43% of the units recorded in the RSC and ACA were significantly more active during PS than during aWK and SWS, respectively. In addition, neuronal discharge of RSC but not of ACA neurons increased just after the peak of hippocampal theta wave. Our results show for the first time that RSC neurons display enhanced spiking in synchrony with theta specifically during PS. We propose that activation of RSC neurons specifically during PS may play a role in the offline consolidation of spatial memories, and in the generation of vivid perceptual scenery during dreaming.pt_BR
dc.identifier.doihttps://doi.org/10.1523/JNEUROSCI.0026-17.2017
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23676
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectparadoxical sleeppt_BR
dc.subjectelectrophysiologypt_BR
dc.subjecthippocampal thetapt_BR
dc.subjectspatial memoriespt_BR
dc.subjectdreamspt_BR
dc.titleElectrophysiological evidence that the retrosplenial cortex displays a strong and specific activation phased with hippocampal theta during paradoxical (REM) sleeppt_BR
dc.typearticlept_BR

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