Nociceptin/orphanin FQ induces simultaneously anxiolytic and amnesic effects in the mouse elevated T-maze task
| dc.contributor.author | Asth, Laila | |
| dc.contributor.author | Correia, Nataly | |
| dc.contributor.author | Soares, Bruno Lobão | |
| dc.contributor.author | Lima, Thereza C. Monteiro de | |
| dc.contributor.author | Guerrini, Remo | |
| dc.contributor.author | Calo', Girolamo | |
| dc.contributor.author | Soares-Rachetti, Vanessa P. | |
| dc.contributor.author | Gavioli, Elaine C. | |
| dc.date.accessioned | 2022-10-25T21:30:41Z | |
| dc.date.available | 2022-10-25T21:30:41Z | |
| dc.date.issued | 2014-10-16 | |
| dc.description.resumo | Studies have shown a close relationship between anxiety and aversive memory processing, but few animal models are suitable for investigating the effects of a given compound on anxiety and memory simultaneously. A growing body of evidence suggests anxiolytic and amnesic effects of nociceptin/orphanin FQ (N/OFQ). The mouse elevated Tmaze (ETM) has been shown to detect the effects of drugs on anxiety and memory at the same time. In this study, the effects of intracerebroventricular N/OFQ injected before or immediately after training session were assessed in the ETM task. When pretraining injected, N/OFQ 0.1 nmol significantly decreased the latency to enter an open arm in the training session compared to control, which is suggestive of anxiolysis. In addition, N/OFQ (0.1 and 1 nmol) significantly reduced the latency to enter an open arm during the test session compared to control, thus suggesting memory impairments. However, when N/OFQ was administered posttraining, it did not affect memory retrieval. No alterations in locomotion were detected in N/OFQ-treated mice in the open field test. In conclusion, these findings are discussed considering the simultaneous anxiolytic and amnesic effects of N/OFQ. | pt_BR |
| dc.identifier.citation | SOARES, Bruno Lobão et al. Nociceptin/orphanin FQ induces simultaneously anxiolytic and amnesic effects in the mouse elevated T-maze task. Naunyn-Schmiedeberg´s Archives of Pharmacology, v. 388, p. 33-41, 2015. Disponível em: <https://link.springer.com/article/10.1007%2Fs00210-014-1055-4>. Acesso em: 23 mar. 2018. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1007/s00210-014-1055-4 | |
| dc.identifier.issn | 1432-1912 | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/49628 | |
| dc.language | en | pt_BR |
| dc.publisher | Springer | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Anxiety | pt_BR |
| dc.subject | Memory | pt_BR |
| dc.subject | Nociceptin/orphanin FQ | pt_BR |
| dc.subject | Elevated T-maze task | pt_BR |
| dc.title | Nociceptin/orphanin FQ induces simultaneously anxiolytic and amnesic effects in the mouse elevated T-maze task | pt_BR |
| dc.type | article | pt_BR |