Avaliação In Vivo da biocompatibilidade Subcutânea de Cimentos Experimentais à base de Cimento Portland e Óxido de Nióbio

Abstract

Introduction: The precision sealing cements are antimicrobial, proven, regenerative and biocompatible. Objectives: To ensure the subcutaneous biocompatibility of two experimental filling cements based on Portland cement and the different properties of the radiopacific agent nitrogen in the subcutaneous tissue of rats. Material and Method: This is an in vivo study, characterized by the implantation of polyethylene tubes on the back of rats containing: Positive control (CP) - MTA Angelus; Cement F6, Cement F7; Negative control (CN) - empty tube. The animals were euthanized on the 7th and 14th day. These techniques are processed for histological analysis using hematoxylin and eosin (HE) and Von Kossa colors. These data are subjected to the Kruskal-Wallis test between groups at the same time and the Mann-Whitney test between times for the same group. The significance level was set at 95% (p < 0.05). Results: There was no statistically significant difference in inflammation between the 7th day (p>0.05) and 14th day (p>0.05) groups. Comparing the intragroup inflammatory response, between days 7 and 14, there was a significant reduction in inflammation in groups CP, F6 and F7 (p<0.05). All our cements are positive for Von Kossa staining in our times. Conclusion: It is concluded that the addition of nitrogen oxide to Portland cement results in no loss of material with low inflammatory response and deposition of calcium crystals without injury to the subcutaneous tissue.