Anti-inflammatory agents as modulators of the inflammation in adipose tissue: a systematic review

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dc.contributor.authorMorais, Ana Heloneida de Araujo
dc.contributor.authorNascimento, Sara Sayonara da Cruz
dc.contributor.authorQueiroz, Jaluza Luana Carvalho de
dc.contributor.authorMedeiros, Amanda Fernandes de
dc.contributor.authorNunes, Ana Clara de França
dc.contributor.authorPiuvezam, Grasiela
dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorPassos, Thais Souza
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-07-20T21:15:13Z
dc.date.available2023-07-20T21:15:13Z
dc.date.issued2022
dc.description.resumoObesity is characterized by an adipose tissue mass expansion that presents a risk to health, associated with a chronic increase in circulating inflammatory mediators. Anti-inflammatory agents are an obesity alternative treatment. However, the lack of effective agents indicates the need to assess the mechanisms and identify effective therapeutic targets. The present work identified and described the mechanisms of action of anti-inflammatory agents in adi pose tissue in experimental studies. The review was registered in the International Prospec tive Registry of Systematic Reviews (PROSPERO—CRD42020182897). The articles’ selection was according to eligibility criteria (PICOS). The research was performed in PubMed, ScienceDirect, Scopus, Web of Science, VHL, and EMBASE. The methodological quality evaluation was assessed using SYRCLE. Initially, 1511 articles were selected, and at the end of the assessment, 41 were eligible. Among the anti-inflammatory agent classes, eight drugs, 28 natural, and five synthetic compounds were identified. Many of these anti inflammatory agents act in metabolic pathways that culminate in the inflammatory cytokines expression reduction, decreasing the macrophages infiltration in white and adipose tissue and promoting the polarization process of type M1 to M2 macrophages. Thus, the article cla rifies and systematizes these anti-inflammatory agents’ mechanisms in adipose tissue, pre senting targets relevant to future research on these pathways.pt_BR
dc.identifier.citationNASCIMENTO, Sara Sayonara da Cruz et al. Anti-inflammatory agents as modulators of the inflammation in adipose tissue: a systematic review. Plos one, v. 17, n. 9, p. e0273942, 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0273942
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/53979
dc.languageenpt_BR
dc.publisherPlos Onept_BR
dc.subjectAnti-inflammatory agentspt_BR
dc.subjectsystematic reviewpt_BR
dc.subjectinflammationpt_BR
dc.subjectadipose tissuept_BR
dc.titleAnti-inflammatory agents as modulators of the inflammation in adipose tissue: a systematic reviewpt_BR
dc.typearticlept_BR

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