Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory

dc.contributor.author	Katche, Cynthia
dc.contributor.author	Dorman, Guido
dc.contributor.author	Slipczuk, Leandro
dc.contributor.author	Cammarota, Martín Pablo
dc.contributor.author	Medina, Jorge H.
dc.date.accessioned	2017-06-01T11:55:06Z
dc.date.available	2017-06-01T11:55:06Z
dc.date.issued	2013
dc.description.resumo	Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.	pt_BR
dc.identifier.doi	10.1101/lm.030080.112
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23321
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	memory	pt_BR
dc.subject	cortical plasticity	pt_BR
dc.subject	post-training macromolecular synthesis	pt_BR
dc.subject	retrosplenial cortex	pt_BR
dc.title	Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory	pt_BR
dc.type	article	pt_BR

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