m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals

Cavarsan, Clarissa Fantin; Avanzi, Renata Della Torre; Queiroz, Claudio Marcos Teixeira de; Xavier, Gilberto Fernando; Mello, Luiz Eugênio; Covolan, Luciene

m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals

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dc.contributor.author	Cavarsan, Clarissa Fantin
dc.contributor.author	Avanzi, Renata Della Torre
dc.contributor.author	Queiroz, Claudio Marcos Teixeira de
dc.contributor.author	Xavier, Gilberto Fernando
dc.contributor.author	Mello, Luiz Eugênio
dc.contributor.author	Covolan, Luciene
dc.date.accessioned	2018-11-13T12:30:13Z
dc.date.available	2018-11-13T12:30:13Z
dc.date.issued	2011-08
dc.description.resumo	n the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment.	pt_BR
dc.identifier.citation	CAVARSAN, C. F. et al. m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals. Aging Dis, v. 2, n. 4, p. 301-307, ago./2011.	pt_BR
dc.identifier.issn	2152-5250
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/26109
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Aging	pt_BR
dc.subject	Epilepsy	pt_BR
dc.subject	Hippocampus	pt_BR
dc.subject	Pilocarpine	pt_BR
dc.subject	m1 ACh receptor	pt_BR
dc.title	m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals	pt_BR
dc.type	article	pt_BR