The genomic profile associated with risk of severe forms of COVID-19 in amazonian native american populations

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dc.contributor.authorAstana, Lucas Favacho
dc.contributor.authorSilva, Thays Amâncio
dc.contributor.authorGellen, Laura Patrícia Albarello
dc.contributor.authorVieira, Giovana Miranda
dc.contributor.authorAssunção, Letícia Almeida de
dc.contributor.authorLeitão, Luciana Pereira Colares
dc.contributor.authorSilva, Natasha Monte da
dc.contributor.authorCoelho, Rita de Cássia Calderaro
dc.contributor.authorAlcântara, Angélica Leite de
dc.contributor.authorVinagre, Lui Wallacy Morikawa Souza
dc.contributor.authorRodrigues, Juliana Carla Gomes
dc.contributor.authorLeal, Diana Feio da Veiga Borges
dc.contributor.authorFernandes, Marianne Rodrigues Fernandes
dc.contributor.authorSouza, Sandro José de
dc.contributor.authorKroll, José Eduardo
dc.contributor.authorSantos, André Mauricio Riberio dos
dc.contributor.authorBurbano, Rommel Mario Rodríguez Burbano
dc.contributor.authorGuerreiro, João Farias
dc.contributor.authorAssumpção, Paulo Pimentel de
dc.contributor.authorSantos, Ândrea Campos Ribeiro dos
dc.contributor.authorSantos, Sidney Emanuel Batista dos
dc.contributor.authorSantos, Ney Pereira Carneiro dos.
dc.date.accessioned2022-05-02T17:22:37Z
dc.date.available2022-05-02T17:22:37Z
dc.date.issued2022-04-01
dc.description.resumoGenetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, XCR1, and ABO genes with the risk of severe forms of COVID-19 in Amazonian Native Americans, and to compare the frequencies with continental populations. The study population was composed of 64 Amerindians from the Amazon region of northern Brazil. The difference in frequencies between the populations was analyzed using Fisher’s exact test, and the results were significant when p ≤ 0.05. We investigated 64 polymorphisms in 7 genes; we studied 47 genetic variants that were new or had impact predictions of high, moderate, or modifier. We identified 15 polymorphisms with moderate impact prediction in 4 genes (ABO, CXCR6, FYCO1, and SLC6A20). Among the variants analyzed, 18 showed significant differences in allele frequency in the NAM population when compared to others. We reported two new genetic variants with modifier impact in the Amazonian population that could be studied to validate the possible associations with COVID-19 outcomes. The genomic profile of Amazonian Native Americans may be associated with protection from severe forms of COVID-19. This work provides genomic data that may help forthcoming studies to improve COVID-19 outcomespt_BR
dc.identifier.citationASTANA, Lucas Favacho; SILVA, Thays Amâncio; GELLEN, Laura Patrícia Albarello; VIEIRA, Giovana Miranda; ASSUNÇÃO, Letícia Almeida de; LEITÃO, Luciana Pereira Colares; SILVA, Natasha Monte da; COELHO, Rita de Cássia Calderaro; ALCÂNTARA, Angélica Leite de; VINAGRE, Lui Wallacy Morikawa Souza; RODRIGUES, Juliana Carla Gomes; LEAL, Diana Feio da Veiga Borges; FERNANDES, Marianne Rodrigues Fernandes; SOUZA, Sandro José de; KROLL, José Eduardo; SANTOS, André Mauricio Riberio dos; BURBANO, Rommel Mario Rodríguez Burbano; GUERREIRO, João Farias; ASSUMPÇÃO, Paulo Pimentel de; SANTOS, Ândrea Campos Ribeiro dos; SANTOS, Sidney Emanuel Batista dos; SANTOS, Ney Pereira Carneiro dos. The genomic profile associated with risk of severe forms of COVID-19 in amazonian native american populations. Journal Of Personalized Medicine, Basiléia (Suíça), v. 12, n. 4, p. 1-12, abr. 2022. Disponível em: https://www.mdpi.com/2075-4426/12/4/554/htm. Acesso em: 29 abr. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.3390/jpm12040554
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/47075
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCOVID-19pt_BR
dc.subjectGenept_BR
dc.subjectRisk factorpt_BR
dc.subjectGenetic variantpt_BR
dc.titleThe genomic profile associated with risk of severe forms of COVID-19 in amazonian native american populationspt_BR
dc.typearticlept_BR

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