Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework

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dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorKosek, Margaret
dc.contributor.authorGuerrant, Richard L.
dc.contributor.authorKang, Gagandeep
dc.contributor.authorBhutta, Zulfiqar
dc.contributor.authorYori, Pablo Peñataro
dc.contributor.authorGratz, Jean
dc.contributor.authorGottlieb, Michael
dc.contributor.authorLang, Dennis
dc.contributor.authorLee, Gwenyth Oneill
dc.contributor.authorHaque, Rashidul
dc.contributor.authorMason, J. Carl
dc.contributor.authorAhmed, Tahmeed
dc.contributor.authorLima, Aldo Ângelo Moreira
dc.contributor.authorPetri, William A.
dc.contributor.authorHoupt, Eric
dc.contributor.authorOlortegui, Maribel Paredes
dc.contributor.authorSeidman, Jessica Couvillion
dc.contributor.authorMduma, Estomih
dc.contributor.authorSamie, Amidou
dc.contributor.authorBabji, Sudhir
dc.date.accessioned2024-02-27T20:12:16Z
dc.date.available2024-02-27T20:12:16Z
dc.date.issued2014-11
dc.description.resumoIndividuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing worldpt_BR
dc.identifier.citationKOSEK, Margaret; GUERRANT, Richard L.; KANG, Gagandeep; BHUTTA, Zulfiqar; YORI, Pablo Peñataro; GRATZ, Jean; GOTTLIEB, Michael; LANG, Dennis; LEE, Gwenyth Oneill; HAQUE, Rashidul; MASON, J. Carl; AHMED, Tahmeed; LIMA, Aldo Ângelo Moreira; PETRI, William A.; HOUPT, Eric; OLORTEGUI, Maribel Paredes; SEIDMAN, Jessica Couvillion; MDUMA, Estomih; SAMIE, Amidou; BABJI, Sudhir. Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework. Clinical Infectious Diseases, [S.l.], v. 59, p. 239-247, 1 nov. 2014. DOI: 10.1093/cid/ciu457. Disponível em: https://academic.oup.com/cid/article/59/suppl_4/S239/280484. Acesso em: 5 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1093/cid/ciu457
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57698
dc.languageenpt_BR
dc.publisherClinical Infectious Diseasespt_BR
dc.subjectEnvironmental enteropathypt_BR
dc.subjectInfant growth failurept_BR
dc.subjectIntestinal infectionspt_BR
dc.subjectLactulose mannitol testpt_BR
dc.subjectTropical enteropathypt_BR
dc.titleAssessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic frameworkpt_BR
dc.typearticlept_BR

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