Biomarkers of zinc and copper status and associated factors in outpatients with ischemic and non-ischemic heart failure

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dc.contributor.authorLima, Severina Carla Vieira Cunha
dc.contributor.authorFreire, Fernanda Lambert de Andrade
dc.contributor.authorKomatsu, Raquel Costa Silva Dantas
dc.contributor.authorLira, Niethia Regina Dantas de
dc.contributor.authorDiniz, Rosiane Viana Zuza
dc.contributor.authorBarbosa Junior, Fernando
dc.contributor.authorPedrosa, Lucia Fatima Campos
dc.contributor.authorEvangelista, Karine Cavalcanti Mauricio Sena
dc.contributor.authorIDhttps://orcid.org/0000-0001-8268-1986pt_BR
dc.date.accessioned2025-02-05T20:00:06Z
dc.date.available2025-02-05T20:00:06Z
dc.date.issued2022
dc.description.resumoBackground: Few studies have explored the impact of ischemic and non-ischemic etiologies of heart failure and other factors associated with heart failure on zinc and copper status. This study examined zinc and copper status in 80 outpatients with ischemic (n ¼ 36) and non-ischemic (n ¼ 44) heart failure and associations with biodemographic, clinical, biochemical, and nutri- tional parameters. Materials: Biomarkers of plasma zinc and copper, copper-zinc ratio, 24-h urinary zinc excretion, ceruloplasmin, and dietary intake of zinc and copper were assessed. Plasma zinc and copper and urinary zinc were measured by inductively coupled plasma mass spectrometry (ICP-MS). Results: Patients with ischemic heart failure showed lower dietary zinc intake and higher dietary copper intake (both p ¼ 0.02). Zinc and copper in plasma, copper-zinc ratio, ceruloplasmin, and 24-h urinary zinc excretion showed no statistical differences between the groups (all p 0.05). An inverse association was found between age (b ¼ 0.001; p ¼ 0.005) and the use of diuretics (b ¼ -0.047; p ¼ 0.013) and plasma zinc. Copper levels in plasma (b = 0.001; p < 0.001), and albumin (b ¼ 0.090; p<0.001) were directly associated with plasma zinc. A positive association was found between ceruloplasmin (b ¼ 0.011; p < 0.001), gamma-glutamyl transferase (b ¼ 0.001; p < 0.001), albumin (b ¼ 0.077; p ¼ 0.001), and high-sensitivity c-reactive protein (b ¼ 0.001; p ¼ 0.024) and plasma copper. Conclusion: Zinc and copper biomarkers in clinically stable patients with heart failure did not seem to be responsive to the differences in zinc and copper intake observed in this study, regard- less of heart failure etiology. The predictors of plasma zinc and copper levels related to oxidative stress and inflammation should be monitored in heart failure clinical practice.pt_BR
dc.identifier.citationFREIRE, Fernanda Lambert de Andrade; KOMATSU, Raquel Costa Silva Dantas; LIRA, Niethia Regina Dantas de; DINIZ, Rosiane Viana Zuza; LIMA, Severina Carla Vieira Cunha; BARBOSA JUNIOR, Fernando; PEDROSA, Lucia Fatima Campos; EVANGELISTA, Karine Cavalcanti Mauricio Sena. Biomarkers of Zinc and Copper Status and Associated Factors in Outpatients with Ischemic and Non-Ischemic Heart Failure. Journal of the american college of nutrition, v. 1, p. 1-9, 2021. DOI: https://doi.org/10.1080/07315724.2021.1878069. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33570472/. Acesso em 02 dez. 2024.pt_BR
dc.identifier.doihttps://doi.org/10.1080/07315724.2021.1878069
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/62514
dc.languageenpt_BR
dc.publisherJournal of the american college of nutritionpt_BR
dc.subjectHeart failurept_BR
dc.subjectZincpt_BR
dc.subjectCopperpt_BR
dc.subjectNutritional statuspt_BR
dc.subjectBiomarkerspt_BR
dc.titleBiomarkers of zinc and copper status and associated factors in outpatients with ischemic and non-ischemic heart failurept_BR
dc.typearticlept_BR

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