Novel markers for OLM interneurons in the hippocampus

Mikulovic, Sanja; Restrepo, C. Ernesto; Hilscher, Markus M.; Kullander, Klas; Leão, Richardson Naves

Novel markers for OLM interneurons in the hippocampus

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dc.contributor.author	Mikulovic, Sanja
dc.contributor.author	Restrepo, C. Ernesto
dc.contributor.author	Hilscher, Markus M.
dc.contributor.author	Kullander, Klas
dc.contributor.author	Leão, Richardson Naves
dc.date.accessioned	2017-05-29T17:35:56Z
dc.date.available	2017-05-29T17:35:56Z
dc.date.issued	2015-06-02
dc.description.resumo	Oriens-lacunosum moleculare (OLM) cells are a major subclass of hippocampal interneurons involved in controlling synaptic plasticity in Shaffer collateral synapses (Leão et al., 2012) and electrogenesis in pyramidal cell (PC) dendrites (Lovett-Barron et al., 2012). Their firing phase is locked with theta oscillations, which imply a role for these cells in theta rhythmogenesis (Klausberger and Somogyi, 2008; Forro et al., 2015). OLM interneurons also appear to be key in the pathophysiology of epilepsy (Dugladze et al., 2007) and is the most vulnerable interneuron population in models of epilepsy (Dinocourt et al., 2003). Somatostatin has been frequently used as a molecular marker for identification of OLM cells (Forro et al., 2015). Two recent studies suggest that the OLM cell population is heterogeneous. First, the expression of cholinergic receptor, nicotinic, alpha polypeptide 2 (Chrna2) seems to be restricted to OLM interneurons neurons of CA1 (Leão et al., 2012). Second, a subset of OLM interneurons that expresses the 5HT3a receptor is derived from the caudal ganglionic eminence and do not entrain to gamma oscillations. In contrast, OLM interneurons derived from the medial ganglionic eminence partially phase lock to in vitro gamma oscillations and do not express 5HT3a receptors (Chittajallu et al., 2013). Further, other dendritic targeting interneurons in the hippocampus also express somatostatin (Lovett-Barron et al., 2014). Hence, functional studies of OLM cell in hippocampal function have been targeting a relatively heterogenous cell population.	pt_BR
dc.identifier.doi	10.3389/fncel.2015.00201
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23188
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	interneuron	pt_BR
dc.subject	Oriens-lacunosum moleculare	pt_BR
dc.subject	somatostatin	pt_BR
dc.subject	hippocampus	pt_BR
dc.subject	Chrna2	pt_BR
dc.title	Novel markers for OLM interneurons in the hippocampus	pt_BR
dc.type	article	pt_BR