NMDARs control object recognition memory destabilization and reconsolidation

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dc.contributor.authorRossato, Janine Inez
dc.contributor.authorRadiske, Andressa
dc.contributor.authorGonzalez, Maria Carolina
dc.contributor.authorApolinário, Gênedy Karielly da Silva
dc.contributor.authorAraújo, Raquel Lúcia Souto de
dc.contributor.authorBevilaqua, Lia Rejane Muller
dc.contributor.authorCammarota, Martín Pablo
dc.date.accessioned2023-04-25T19:09:10Z
dc.date.available2023-04-25T19:09:10Z
dc.date.issued2023-04
dc.description.resumoObject recognition memory (ORM) allows identification of previously encountered items and is therefore crucial for remembering episodic information. In rodents, reactivation during recall in the presence of a novel object destabilizes ORM and initiates a Zif268 and protein synthesis-dependent reconsolidation process in the hippocampus that links the memory of this object to the reactivated recognition trace. Hippocampal NMDA receptors (NMDARs) modulate Zif268 expression and protein synthesis and regulate memory stability but their possible involvement in the ORM destabilization/reconsolidation cycle has yet to be analyzed in detail. We found that, in adult male Wistar rats, intra dorsal-CA1 administration of the non-subunit selective NMDAR antagonist AP5, or of the GluN2A subunit-containing NMDAR antagonist TCN201, 5 min after an ORM reactivation session in the presence of a novel object carried out 24 h post-training impaired retention 24 h later. In contrast, pre-reactivation administration of the GluN2B subunit-containing NMDAR antagonist RO25-6981 had no effect on ORM recall or retention but impeded the amnesia caused by Zif268 silencing and protein synthesis inhibition in dorsal CA1. Our results indicate that GluN2B-containing hippocampal NMDARs are necessary for ORM destabilization whereas GluN2A-containing NMDARs are involved in ORM reconsolidation, and suggest that modulation of the relative activity of these receptor subtypes during recall regulates ORM persistencept_BR
dc.identifier.citationROSSATO, Janine I.; RADISKE, Andressa; GONZALEZ, Maria Carolina; APOLINÁRIO, Gênedy; ARAÚJO, Raquel L. S.; BEVILAQUA, Lia R. M.; CAMMAROTA, Martín. NMDARs control object recognition memory destabilization and reconsolidation. Brain Research Bulletin, [S. l.], v. 197, p. 42-48, jun. 2023. Doi: http://dx.doi.org/10.1016/j.brainresbull.2023.03.013. Disponível em: https://www.sciencedirect.com/science/article/pii/S0361923023000692?via%3Dihub. Acesso em: 25 abr. 2023.pt_BR
dc.identifier.doi10.1016/j.brainresbull.2023.03.013
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/52229
dc.languageenpt_BR
dc.publisherElsevier BVpt_BR
dc.rightsAtribuição-NãoComercial-SemDerivados 3.0 Brasil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectHippocampuspt_BR
dc.subjectRecallpt_BR
dc.subjectTCN201pt_BR
dc.subjectAP5pt_BR
dc.subjectRO25–6981pt_BR
dc.subjectMemory consolidationpt_BR
dc.titleNMDARs control object recognition memory destabilization and reconsolidationpt_BR
dc.typearticlept_BR

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