Consolidation of Object Recognition Memory Requires HRI Kinase-Dependent Phosphorylation of eIF2a in the Hippocampus

Página do item simplificado Estatísticas
dc.contributor.authorILL-Raga, Gerard
dc.contributor.authorKohler, Cristiano
dc.contributor.authorRadiske, Andressa
dc.contributor.authorLima, Ramón H.
dc.contributor.authorRosen, Mark D.
dc.contributor.authorMuñoz, Francisco J.
dc.contributor.authorCammarota, Martín Pablo
dc.date.accessioned2017-05-31T17:23:20Z
dc.date.available2017-05-31T17:23:20Z
dc.date.issued2013
dc.description.resumoLocal control of protein synthesis at synapses is crucial for synaptic plasticity and memory formation. However, little is known about the signals coupling neurotransmitter release with the translational machinery during these processes. Here, we studied the involvement of heme-regulated inhibitor (HRI) kinase, a kinase activated by nitric oxide that phosphorylates eukaryotic initiation factor 2α (eIF2α), in object recognition (OR) memory consolidation. Phosphorylated eIF2α mediates two opposing effects upon translation: translational arrest of most mRNAs and translational activation of selected mRNAs bearing specific features in their 5'untranslated regions (5'UTRs). We found that HRI kinase activation in the CA1 region of the dorsal hippocampus is necessary for retention of OR memory in rats. Accordingly, learning induced a transient increase in the phosphorylation state of eIF2α in dorsal CA1 which was abolished by the HRI kinase inhibitor N-(2,6-dimethylbenzyl)-6,7-dimethoxy-2H-[1]benzofuro[3,2-c]pyrazol-3-amine hydrochloride (AMI). The increase in p-eIF2α was associated with increased expression of BACE1 and activating transcription factor 4, two proteins containing eIF2α-responsive 5'UTRs in their mRNAs that play a key role in synaptic plasticity. Our data suggests that learning promotes the transient phosphorylation of eIF2α to allow for translation of specific 5'UTR-mRNAs through a process requiring HRI kinase activation.pt_BR
dc.identifier.doi10.1002/hipo.22113
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23295
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjecteIF2apt_BR
dc.subjectmemorypt_BR
dc.subjecthippocampuspt_BR
dc.subjectNOpt_BR
dc.subjectHRI kinasept_BR
dc.subjectBACE1pt_BR
dc.subjectATF4pt_BR
dc.subjectSal003pt_BR
dc.subjectN-(2,6-dimethylbenzyl)-6,7-dimethoxy-2H-[1]benzofuro [3,2-c]pyrazol-3-amine hydrochloridept_BR
dc.titleConsolidation of Object Recognition Memory Requires HRI Kinase-Dependent Phosphorylation of eIF2a in the Hippocampuspt_BR
dc.typearticlept_BR

Arquivos

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM