Sex steroids and brain-derived neurotrophic factor interactions in the nervous system: a comprehensive review of scientific data

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dc.contributor.authorAssis, Gilmara Gomes de
dc.contributor.authorSousa, Maria Bernardete Cordeiro de
dc.contributor.authorMurawska-Ciałowicz, Eugenia
dc.date.accessioned2025-03-14T13:10:16Z
dc.date.available2025-03-14T13:10:16Z
dc.date.issued2025-03
dc.description.resumoSex steroids and the neurotrophin brain-derived neurotrophic factor (BDNF) participate in neural tissue formation, phenotypic differentiation, and neuroplasticity. These processes are essential for the health and maintenance of the central nervous system. Aim: The aim of our review is to elucidate the interaction mechanisms between BDNF and sex steroids in neuronal function. Method: A series of searches were performed using Mesh terms for androgen/receptors, estrogen/receptors, and BDNF/receptors, and a collection of the scientific data available on PubMed up to February 2025 about mechanical interactions between BDNF and sex steroids was included in this literature review. Discussion: This review discussed the influence of sex steroids on the formation and/or maintenance of neural circuits via different mechanisms, including the regulation of BDNF expression and signaling. Estrogens exert a time- and region-specific effect on BDNF synthesis. The nuclear estrogen receptor can directly regulate BDNF expression, independently of the presence of estrogen, in neuronal cells, whereas progesterone and testosterone upregulate BDNF expression via their specific nuclear receptors. In addition, testosterone has a positive effect on BDNF release by glial cells, which lack androgen receptorspt_BR
dc.identifier.citationASSIS, Gilmara Gomes de; SOUSA, Maria Bernardete Cordeiro de; MURAWSKA-CIAłOWICZ, Eugenia. Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: a comprehensive review of scientific data. International Journal Of Molecular Sciences, [S. l.], v. 26, n. 6, p. 2532, mar. 2025. Doi: http://dx.doi.org/10.3390/ijms26062532. Disponível em: https://www.mdpi.com/1422-0067/26/6/2532. Acesso em: 14 mar. 2025pt_BR
dc.identifier.doi10.3390/ijms26062532
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/63013
dc.languageenpt_BR
dc.publisherMDPI AGpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectEstrogenpt_BR
dc.subjectEstradiolpt_BR
dc.subjectTestosteronept_BR
dc.subjectProgesteronept_BR
dc.subjectBrain-derived neurotrophic factorpt_BR
dc.subjectNervous systempt_BR
dc.titleSex steroids and brain-derived neurotrophic factor interactions in the nervous system: a comprehensive review of scientific datapt_BR
dc.typearticlept_BR

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