Development of moringa oil nanoemulsion for treatment of chronic wounds

dc.contributor.advisorEgito, Eryvaldo Sócrates Tabosa do
dc.contributor.advisor-co1Oliveira, Wógenes Nunes de
dc.contributor.advisor-co1IDhttps://orcid.org/0000-0002-1564-906X
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/1190614005046544
dc.contributor.advisorIDhttps://orcid.org/0000-0002-2180-3991
dc.contributor.advisorLatteshttp://lattes.cnpq.br/6907806915889763
dc.contributor.authorLima, Wallacy Silva de
dc.contributor.authorIDhttps://orcid.org/0009-0003-0624-5682
dc.contributor.authorLatteshttp://lattes.cnpq.br/1073079461813835
dc.contributor.referees1Silva Júnior, Arnóbio Antônio da
dc.contributor.referees1IDhttps://orcid.org/0000-0002-2180-3991
dc.contributor.referees1Latteshttp://lattes.cnpq.br/2593509584288129
dc.contributor.referees2Veríssimo, Lourena Mafra
dc.contributor.referees2IDhttps://orcid.org/0000-0002-7516-1787
dc.contributor.referees2Latteshttp://lattes.cnpq.br/9173400981540256
dc.contributor.referees3IDhttps://orcid.org/0000-0002-9289-0455
dc.date.accessioned2025-07-17T13:10:22Z
dc.date.available2025-07-17T13:10:22Z
dc.date.issued2025-06-25
dc.description.abstractBackground/Objectives: Moringa oleifera Lam is highlighted in literature for its bioactive 10 properties as anti-inflammatory, antioxidant, and wound-healing, which are mainly at- 11 tributed to the fixed oil extracted from its seeds. Nevertheless, the oil organoleptic char- 12 acteristics as odor, viscosity, texture, and susceptibility to oxidation limit the in natura oil 13 topical application. Therefore, the aim of this study was the development of nanoemul- 14 sions containing moringa oil (MO) as a nanotechnological approach to enable a suitable 15 topical use. Methods: The Quality by Design (QbD) approach by Design of Experiments 16 (DoE) tool was used to determine the required HLB value (rHLB) of MO and develop the 17 nanoemulsion. Subsequently nanoemulsion was characterized by hydrodynamic droplet 18 size, polydispersity index, and zeta potential, followed by a preliminary stability study 19 under different storage conditions (4 ± 2 °C, 25 ± 2 °C, 45 ± 2 °C). Results: The required 20 HLB identified through DoE was 12.27. The nanoemulsion obtained by the QbD strategy 21 was composed by 10% of MO, 12% surfactant mixture (Kolliphor® RH 40 and Span® 80), 22 and 78% water. This composition produced a nanoemulsion with an average droplet size 23 of 89.94 ± 5.34 d.nm, a polydispersity index (PdI) of 0.14 ± 0.02, and a zeta potential of - 24 9.55 ± 0.195 mV. The final formulation exhibited typical characteristics of nanoemulsified 25 systems and adequate physicochemical stability for 90 days, demonstrating a promising 26 topical product. Conclusions: These results indicate the successful development and pre- 27 liminary characterization and stability for a nanoemulsion containing MO, paving the 28 way for its further evaluation and use on wound healing.
dc.description.resumoBackground/Objectives: Moringa oleifera Lam is highlighted in literature for its bioactive 10 properties as anti-inflammatory, antioxidant, and wound-healing, which are mainly at- 11 tributed to the fixed oil extracted from its seeds. Nevertheless, the oil organoleptic char- 12 acteristics as odor, viscosity, texture, and susceptibility to oxidation limit the in natura oil 13 topical application. Therefore, the aim of this study was the development of nanoemul- 14 sions containing moringa oil (MO) as a nanotechnological approach to enable a suitable 15 topical use. Methods: The Quality by Design (QbD) approach by Design of Experiments 16 (DoE) tool was used to determine the required HLB value (rHLB) of MO and develop the 17 nanoemulsion. Subsequently nanoemulsion was characterized by hydrodynamic droplet 18 size, polydispersity index, and zeta potential, followed by a preliminary stability study 19 under different storage conditions (4 ± 2 °C, 25 ± 2 °C, 45 ± 2 °C). Results: The required 20 HLB identified through DoE was 12.27. The nanoemulsion obtained by the QbD strategy 21 was composed by 10% of MO, 12% surfactant mixture (Kolliphor® RH 40 and Span® 80), 22 and 78% water. This composition produced a nanoemulsion with an average droplet size 23 of 89.94 ± 5.34 d.nm, a polydispersity index (PdI) of 0.14 ± 0.02, and a zeta potential of - 24 9.55 ± 0.195 mV. The final formulation exhibited typical characteristics of nanoemulsified 25 systems and adequate physicochemical stability for 90 days, demonstrating a promising 26 topical product. Conclusions: These results indicate the successful development and pre- 27 liminary characterization and stability for a nanoemulsion containing MO, paving the 28 way for its further evaluation and use on wound healing.
dc.description.sponsorshipCNPq
dc.description.sponsorshipCAPES
dc.identifier.citationLIMA, Wallacy Silva de. Development of moringa oil nanoemulsion for treatment of chronic wounds. Orientador: Eryvaldo Sócrates Tabosa do Egito. 2025. 28 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2025.
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/64472
dc.language.isoen_US
dc.publisherUniversidade Federal do Rio Grande do Norte
dc.publisher.countryBrazil
dc.publisher.departmentDepartamento Farmácia
dc.publisher.initialsUFRN
dc.publisher.programFarmácia
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazilen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/
dc.subjectMoringa oleifera
dc.subjectQuality by Design
dc.subjectDesign of Experiments
dc.subjectWound Healing
dc.subject.cnpqCIENCIAS DA SAUDE::FARMACIA
dc.titleDevelopment of moringa oil nanoemulsion for treatment of chronic wounds
dc.title.alternativeDevelopment of moringa oil nanoemulsion for treatment of chronic wounds
dc.typebachelorThesis

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