Tamarind (Tamarindus indica L.) seed a candidate protein source with potential for combating SARS-CoV-2 infection in obesity

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dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.contributor.authorMedeiros, Amanda F. de
dc.contributor.authorMedeiros, Isaiane
dc.contributor.authorLima, Vanessa C. O. de
dc.contributor.authorLuz, Anna B. S.
dc.contributor.authorMaciel, Bruna L. L.
dc.contributor.authorPassos, Thaís S.
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-08-01T18:26:56Z
dc.date.available2023-08-01T18:26:56Z
dc.date.issued2021
dc.description.resumoIntroduction: Obesity and coronavirus disease (COVID)-19 are overlapping pandemics, and one might worsen the other. Methods: This narrative review discusses one of the primary mechanisms to initiate acute respiratory distress syndrome, uncontrolled systemic inflammation in COVID-19, and presents a potential candidate for adjuvant treatment. Blocking the S protein binding to angiotensin-converting enzyme 2 (ACE-2) and the 3C-like protease (3CL pro) is an effective strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Results: Host proteases such as FURIN, trypsin, and transmembrane serine protease 2 (TMPRSS) act in S protein activation. Tamarind trypsin inhibitor (TTI) shows several beneficial effects on the reduction of inflammatory markers (tumor necrosis factor α [TNF-α], leptin) and biochemical parameters (fasting glycemia, triglycerides, and very low-density lipoprotein [VLDL]), in addition to improving pancreatic function and mucosal integrity in an obesity model. TTI may inhibit the action of proteases that collaborate with SARS-CoV-2 infection and the neutro phil activity characteristic of lung injury promoted by the virus. Conclusion: Thus, TTI may contribute to combating two severe overlapping problems with high cost and social complex implications, obesity and COVID-19.pt_BR
dc.identifier.citationMORAIS, A. H. A.; MEDEIROS, A. F. ; MEDEIROS, I. ; LIMA, V. C. O. ; LUZ, A. B. S. ; Maciel B L L ; PASSOS, T. S. Tamarind (Tamarindus indica L.) seed a candidate protein source with Potential for combating SARS-CoV-2 infection in obesity. Drug Target Insights, v. 15, p. 5-12, 2021.pt_BR
dc.identifier.doi10.33393/dti.2021.2192
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54326
dc.languageenpt_BR
dc.publisherDrug Target Insightspt_BR
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subject3CLpropt_BR
dc.subjectACE-2pt_BR
dc.subjectCOVID-19pt_BR
dc.subjectFURINpt_BR
dc.subjectHNEpt_BR
dc.subjectInflammationpt_BR
dc.subjectTMPRSSpt_BR
dc.titleTamarind (Tamarindus indica L.) seed a candidate protein source with potential for combating SARS-CoV-2 infection in obesitypt_BR
dc.typearticlept_BR

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