Development of a magnetic system for the treatment of Helicobacter pylori infections

Araújo, José Humberto de; Silva, Érica Lira; Carvalho, Juliana Fernandes; Pontes, Thales Renan Ferreira; Oliveira, Elquio Eleamen; Francelino, Bárbara L.; Medeiros, Aldo da Cunha; Carriço, Arthur da Silva; Egito, Eryvaldo Sócrates Tabosa do

Development of a magnetic system for the treatment of Helicobacter pylori infections

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dc.contributor.author	Araújo, José Humberto de
dc.contributor.author	Silva, Érica Lira
dc.contributor.author	Carvalho, Juliana Fernandes
dc.contributor.author	Pontes, Thales Renan Ferreira
dc.contributor.author	Oliveira, Elquio Eleamen
dc.contributor.author	Francelino, Bárbara L.
dc.contributor.author	Medeiros, Aldo da Cunha
dc.contributor.author	Carriço, Arthur da Silva
dc.contributor.author	Egito, Eryvaldo Sócrates Tabosa do
dc.date.accessioned	2020-06-19T18:29:19Z
dc.date.available	2020-06-19T18:29:19Z
dc.date.issued	2010-03-05
dc.description.resumo	We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications	pt_BR
dc.identifier.citation	SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087.	pt_BR
dc.identifier.doi	10.1016/j.jmmm.2009.02.087
dc.identifier.issn	0304-8853
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/29312
dc.language	en	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Magnetic vectorization	pt_BR
dc.subject	Helicobacter pylori	pt_BR
dc.subject	Magnetite microparticle	pt_BR
dc.subject	Pray drying coating	pt_BR
dc.subject	Superparamagnetic particle	pt_BR
dc.title	Development of a magnetic system for the treatment of Helicobacter pylori infections	pt_BR
dc.type	article	pt_BR