HIF-1alpha expression profile in intratumoral and peritumoral inflammatory cells as a prognostic marker for squamous cell carcinoma of the oral cavity

Mendes, Suzanny Oliveira; Santos, Marcelo dos; Peterle, Gabriela Tonini; Maia, Lucas de Lima; Stur, Elaine; Agostini, Lidiane Pignaton; Carvalho, Marcos Brasilino de; Tajara, Eloiza Helena; Louro, Iúri Drumond; Trivilin, Leonardo Oliveira; Silva-Conforti, Adriana Madeira Álvares da

HIF-1alpha expression profile in intratumoral and peritumoral inflammatory cells as a prognostic marker for squamous cell carcinoma of the oral cavity

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dc.contributor.author	Mendes, Suzanny Oliveira
dc.contributor.author	Santos, Marcelo dos
dc.contributor.author	Peterle, Gabriela Tonini
dc.contributor.author	Maia, Lucas de Lima
dc.contributor.author	Stur, Elaine
dc.contributor.author	Agostini, Lidiane Pignaton
dc.contributor.author	Carvalho, Marcos Brasilino de
dc.contributor.author	Tajara, Eloiza Helena
dc.contributor.author	Louro, Iúri Drumond
dc.contributor.author	Trivilin, Leonardo Oliveira
dc.contributor.author	Silva-Conforti, Adriana Madeira Álvares da
dc.date.accessioned	2021-02-22T17:08:04Z
dc.date.available	2021-02-22T17:08:04Z
dc.date.issued	2014-01-09
dc.description.resumo	The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1alpha subunit is stabilized in hypoxia conditions, creating the HIF-1 nuclear transcription factor. In inflammatory cells, high HIF-1alpha expression induces lymphocytic immunosuppression, decreasing tumoral antigen recognition, which promotes tumor growth. The present work investigated the relationship between HIF-1alpha expression in lymphocytes populating the intratumoral and peritumoral region of 56 patients with oral cancer. Our data indicates a prognostic value for this expression. High HIF-1alpha expression in peritumoral inflammatory cells is significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1alpha expression in tumoral inflammatory cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1alpha expression in peritumoral cells correlates with worse prognosis, independently of intratumoral expression. Low HIF-1alpha in tumor margins and high expression in the tumor was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low expression in tumor and tumor margins. Our results suggest that HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker	pt_BR
dc.identifier.citation	MENDES, Suzanny Oliveira et al. HIF-1alpha expression profile in intratumoral and peritumoral inflammatory cells as a prognostic marker for squamous cell carcinoma of the oral cavity. Plos One, [s. l.], v. 9, n. 1, 2014. Disponível em: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084923&type=printable. Acesso em: 07 jul. 2020. https://doi.org/10.1371/journal.pone.0084923	pt_BR
dc.identifier.doi	10.1371/journal.pone.0084923
dc.identifier.issn	1932-6203 (online)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31589
dc.language	en	pt_BR
dc.publisher	Public Library of Science	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Biomarkers, tumor	pt_BR
dc.subject	Carcinoma, squamous cell	pt_BR
dc.subject	Gene Expression Regulation, neoplastic	pt_BR
dc.subject	Hypoxia-Inducible Factor 1, alpha Subunit	pt_BR
dc.subject	Inflammation, pathology	pt_BR
dc.subject	Lymphocytes, metabolism	pt_BR
dc.title	HIF-1alpha expression profile in intratumoral and peritumoral inflammatory cells as a prognostic marker for squamous cell carcinoma of the oral cavity	pt_BR
dc.type	article	pt_BR