Klebsiella pneumoniae e fatores associados que contribuem para a resistência antimicrobiana: uma revisão de literatura

Abstract

Antimicrobial resistance is currently considered a global crisis and is the expected result of the interaction of microorganisms with the environment, causing the resistance of one or more antimicrobials. Excessive and inappropriate use of antibiotics are amongst the leading causes of antibiotic resistance. Klebsiella pneumoniae is one of the major microorganisms that present resistance to antimicrobials and causes an increase in morbidity and mortality rates in hospital and community infections. The aim of this research is to perform a bibliographic review through scientific databases on the factors that contribute to resistance in the Klebsiella pneumoniae Carbapenemase (KPC) enzyme-producing Klebsiella pneumoniae and Beta-lactamases. K. penumoniae makes use of several virulence factors that allow it to bypass the host immune system and cause infections consequently requiring a correct diagnosis and relying on prevention. Is extremely necessary to limit the spread of resistant K. pneumoniae strains, as well as the development of new antimicrobials to combat hospital infections.