Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival

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dc.contributor.authorArchanjo, Anderson Barros
dc.contributor.authorAssis, Arícia Leone Evangelista Monteiro de
dc.contributor.authorOliveira, Mayara Mota de
dc.contributor.authorMendes, Suzanny Oliveira
dc.contributor.authorBorçoi, Aline Ribeiro
dc.contributor.authorMaia, Lucas de Lima
dc.contributor.authorSouza, Rafael Pereira de
dc.contributor.authorCicco, Rafael de
dc.contributor.authorSaito, Kelly Cristina
dc.contributor.authorKimura, Edna Teruko
dc.contributor.authorCarvalho, Marcos Brasilino de
dc.contributor.authorNunes, Fabio Daumas
dc.contributor.authorTajara, Eloiza H.
dc.contributor.authorSantos, Marcelo dos
dc.contributor.authorNogueira, Breno Valentim
dc.contributor.authorTrivilin, Leonardo Oliveira
dc.contributor.authorPinheiro, Christiano Jorge Gomes
dc.contributor.authorSilva, Adriana Madeira Álvares da
dc.date.accessioned2021-03-31T10:38:14Z
dc.date.available2021-03-31T10:38:14Z
dc.date.issued2020-06-25
dc.description.resumoOral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survivalpt_BR
dc.identifier.citationARCHANJO, Anderson Barros et al. Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. Scientific Reports, [s. l.], v. 10, n. 1, p. 1-10, 25 jun. 2020. Springer Science and Business Media LLC. Disponível em: https://www.nature.com/articles/s41598-020-67270-5. Acesso em: 30 mar. 2021. http://dx.doi.org/10.1038/s41598-020-67270-5pt_BR
dc.identifier.doi10.1038/s41598-020-67270-5
dc.identifier.issn2045-2322 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/32028
dc.languageenpt_BR
dc.publisherNature Researchpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectTobacco use disorderpt_BR
dc.subjectSmokept_BR
dc.subjectCarcinoma, Squamous cellpt_BR
dc.subjectTumor cells, Culturedpt_BR
dc.titleElemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survivalpt_BR
dc.typearticlept_BR

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