Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment andMicroglia Activation after Motor Cortex Excitotoxic Injury

Guimarães-Santos, Adriano; Santos, Diego Siqueira; Santos, Ijair Rogério; Lima, Rafael Rodrigues; Pereira, Antonio; Moura, Lucinewton Silva de; Carvalho Jr., Raul Nunes; Lameira, Osmar; Gomes-Leal, Walace

Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment andMicroglia Activation after Motor Cortex Excitotoxic Injury

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dc.contributor.author	Guimarães-Santos, Adriano
dc.contributor.author	Santos, Diego Siqueira
dc.contributor.author	Santos, Ijair Rogério
dc.contributor.author	Lima, Rafael Rodrigues
dc.contributor.author	Pereira, Antonio
dc.contributor.author	Moura, Lucinewton Silva de
dc.contributor.author	Carvalho Jr., Raul Nunes
dc.contributor.author	Lameira, Osmar
dc.contributor.author	Gomes-Leal, Walace
dc.date.accessioned	2017-05-29T14:12:05Z
dc.date.available	2017-05-29T14:12:05Z
dc.date.issued	2012-11-16
dc.description.resumo	The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent. However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders.We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.	pt_BR
dc.identifier.issn	1741-427X
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23178
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Copaiba Oil-Resin	pt_BR
dc.subject	Neuroprotective	pt_BR
dc.subject	Neutrophil Recruitment	pt_BR
dc.subject	Microglia Activation	pt_BR
dc.title	Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment andMicroglia Activation after Motor Cortex Excitotoxic Injury	pt_BR
dc.type	article	pt_BR