Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine

Pergher, Sibele Berenice Castellã; Oliveira, Artur S.; Alcântara, Ana C.S.

Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine

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dc.contributor.author	Pergher, Sibele Berenice Castellã
dc.contributor.author	Oliveira, Artur S.
dc.contributor.author	Alcântara, Ana C.S.
dc.date.accessioned	2020-07-13T17:16:01Z
dc.date.available	2020-07-13T17:16:01Z
dc.date.issued	2017-06-01
dc.description.resumo	Olanzapine (OLZ) is a drug that is used in the treatment of schizophrenia and other psychoses, and it belongs to the thienobenzodiazepine class. The OLZ molecule has low solubility decreasing bioavailability, but has high permeability in membrane biological being classified as a Class II drug substance according to the Biopharmaceutics Classification System. It was reported many side effects of administering OLZ orally. So, in order to increase the bioavailability of drug and possibly reducing some of side effects, this paper proposes a new material able to controllably release the drug in the body. To control the dissolution rate, this work proposes a system that incorporates the drug into montmorillonite (MMT) dispersed in a mixture of alginate (ALG) and xanthan gum (XG) biopolymers. The proposed hybrids and bionanocomposites were characterized by several physicochemical techniques, including XRD, IR-ATR, TG DTA, SEM-EDS and HPLC. The characterization data confirmed the intercalation of the OLZ into the MMT by the ion exchange process, as well as the interaction of the MMT-OLZ with the biopolymers. The release test, conducted under various pH conditions, showed that the proposed system exhibited a more controlled drug release than commercial tablets, indicating that the ALG-XG/MMT-OLZ bionanocomposite can act as a controlled release system for OLZ	pt_BR
dc.identifier.citation	OLIVEIRA, Artur S.; ALCÂNTARA, Ana C.S.; PERGHER, Sibele Berenice Castellã. Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine. Materials Science And Engineering: C, [s.l.], v. 75, p. 1250-1258, jun. 2017. ISSN 0928-4931. Disponível em https://www.sciencedirect.com/science/article/abs/pii/S092849311631685X?via%3Dihub. Acesso em: 13 jul. 2020. http://dx.doi.org/10.1016/j.msec.2017.03.044	pt_BR
dc.identifier.doi	10.1016/j.msec.2017.03.044
dc.identifier.issn	0928-4931
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/29580
dc.language	en	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Bionanocomposite	pt_BR
dc.subject	Hybrid	pt_BR
dc.subject	Montmorillonite	pt_BR
dc.subject	Xanthan gum	pt_BR
dc.subject	Alginate	pt_BR
dc.subject	Olanzapine	pt_BR
dc.subject	Drug delivery	pt_BR
dc.title	Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine	pt_BR
dc.type	article	pt_BR