fMRI in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia

Liu, Junjie V.; Hirano, Yoshiyuki; Nascimento, George Carlos; Stefanovic, Bojana; Leopold, David A.; Silva, Afonso C.

fMRI in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia

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dc.contributor.author	Liu, Junjie V.
dc.contributor.author	Hirano, Yoshiyuki
dc.contributor.author	Nascimento, George Carlos
dc.contributor.author	Stefanovic, Bojana
dc.contributor.author	Leopold, David A.
dc.contributor.author	Silva, Afonso C.
dc.date.accessioned	2020-07-24T17:23:22Z
dc.date.available	2020-07-24T17:23:22Z
dc.date.issued	2013-09
dc.description.resumo	Functional neuroimaging in animal models is essential for understanding the principles of neurovascular coupling and the physiological basis of fMRI signals that are widely used to study sensory and cognitive processing in the human brain. While hemodynamic responses to sensory stimuli have been characterized in humans, animal studies are able to combine very high resolution imaging with invasive measurements and pharmacological manipulation. To date, most high-resolution studies of neurovascular coupling in small animals have been carried out in anesthetized rodents. Here we report fMRI experiments in conscious, awake common marmosets (Callithrix jacchus), and compare responses to animals anesthetized with propofol. In conscious marmosets, robust BOLD fMRI responses to somatosensory stimulation of the forearm were found in contralateral and ipsilateral regions of the thalamus, primary (SI) and secondary (SII) somatosensory cortex, and the caudate nucleus. These responses were markedly stronger than those in anesthetized marmosets and showed a monotonic increase in the amplitude of the BOLD response with stimulus frequency. On the other hand, anesthesia significantly attenuated responses in thalamus, SI and SII, and abolished responses in caudate and ipsilateral SI. Moreover, anesthesia influenced several other aspects of the fMRI responses, including the shape of the hemodynamic response function and the interareal (SI–SII) spontaneous functional connectivity. Together, these findings demonstrate the value of the conscious, awake marmoset model for studying physiological responses in the somatosensory pathway, in the absence of anesthesia, so that the data can be compared most directly to fMRI in conscious humans	pt_BR
dc.identifier.citation	LIU, J.V.; HIRANO, Y.; NASCIMENTO, G.C. ; STEFANOVIC, B.; LEOPOLD, D.A.; SILVA, A.C.. fMRI in the awake marmoset: Somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia. Neuroimage (Orlando, Fla. Print), v. 78, p. 186-195, 2013.	pt_BR
dc.identifier.doi	10.1016/j.neuroimage.2013.03.038
dc.identifier.issn	1053-8119
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/29721
dc.language	en	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/br/	*
dc.subject	Resting-state functional connectivity	pt_BR
dc.subject	Neuroanesthesia	pt_BR
dc.subject	New world monkey	pt_BR
dc.subject	Functional MRI	pt_BR
dc.subject	Awake non-human primate	pt_BR
dc.title	fMRI in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia	pt_BR
dc.type	article	pt_BR