Alterações na concentração sérica de magnésio induzidas pelo uso de inibidores da bomba de prótons em pacientes críticos

Abstract

Objective: To identify the influence of proton pump inhibitors use on the serum magnesium levels variation in critically ill patients during the intensive care unit stay. Methods: the data gathered during the cross-sectional study, obtained from medical records of patients admitted to the ICU of a tertiary hospital during January to June 2021, were analyzed using the random effects model (CI range: 95%; p < 0.05). Results: proton pump inhibitors were prescribed in 96.6% of the cases, with pantoprazole being the most-prescribed drug. In the random effects statistical analysis model, it was shown that the serum magnesium concentration tends to be reduced with the increase of length of stay and with the concomitant use of pantoprazole, but it increases as there is serum creatinine accumulation in the system. Conclusion: The pantoprazole use in patients admitted to the ICU may favor the serum magnesium depletion over time. Therefore, the clinical impact of this finding requires further investigation.