Nutritional therapy in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis

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dc.contributor.authorPiuvezam, Grasiela
dc.contributor.authorVilar, Mariana Dantas de Carvalho
dc.contributor.authorCoutinho, Karla Monica Dantas
dc.contributor.authorVale, Sancha Helena de Lima
dc.contributor.authorLais, Lucia Leite
dc.contributor.authorMedeiros, Gidyenne Christine Bandeira Silva
dc.contributor.authorBrandao-Neto, Jose
dc.contributor.authorIDhttps://orcid.org/0000-0002-2343-7251pt_BR
dc.date.accessioned2023-11-10T19:57:59Z
dc.date.available2023-11-10T19:57:59Z
dc.date.issued2022
dc.description.resumoIntroduction Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease characterised by the degeneration of motor neurons. Nutritional interventions in ALS are essential and must be based on scientific evidence to provide quality of healthcare, improve the quality of life and increase survival time. Therefore, this protocol of systematic reviews and meta-analyses aims to present a synthesis of evidence-based recommendations to support adequate nutrition therapy for patients with ALS. Methods and analysis The search will be performed using the following databases: PubMed, Excerpta Medica Database (Embase), Scopus, SciELO, Web of Science, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), ScienceDirect, ProQuest and Google Scholar. We will include clinical practice guidelines, treatment protocols, systematic reviews and clinical trials according to the three research questions to be answered related to nutrition therapy and interventions in patients with ALS. This protocol will be developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols. To evaluate the methodological quality of the studies, Appraisal of Guidelines, Research and Evaluation II, Cochrane Risk of Bias 2.0 and Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I) tools will be used. In addition, the Grading of Recommendations Assessment, Development and Evaluation will be used to assess the quality of evidence and the strength of the recommendations. The findings will be summarised and presented descriptively according to the Cochrane Collaboration Handbook and the standard statistical meta-analysis techniques. Ethics and dissemination Ethical approval and human consent are not required because this is a protocol for systematic review and only secondary data will be used. Findings will be published in a peer-reviewed journal and presented at conferences. In case of any changes in this protocol, amendments will be updated in International Prospective Register of Systematic Reviews (PROSPERO) and the modifications will be explained in the final report of this reviewpt_BR
dc.identifier.citationPIUVEZAM, Grasiela; VILAR, Mariana Dantas de Carvalho; COUTINHO, Karla Monica Dantas; VALE, Sancha Helena de Lima; MEDEIROS, Gidyenne Christine Bandeira Silva; LEITE-LAIS, Lucia; BRANDAO-NETO, Jose. Nutritional therapy in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis. Bmj Open, [S.L.], v. 12, n. 8, p. 064086, ago. 2022. BMJ. DOI: http://dx.doi.org/10.1136/bmjopen-2022-064086. Disponível em: https://bmjopen.bmj.com/content/12/8/e064086. Acesso em: 07 nov. 2023.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2022-064086
dc.identifier.issne2044-6055
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55283
dc.languageenpt_BR
dc.publisherBmj Openpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectnutritional therapypt_BR
dc.subjectamyotrophic lateral sclerosispt_BR
dc.subjectneurodegenerativept_BR
dc.titleNutritional therapy in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysispt_BR
dc.typearticlept_BR

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