mTOR inhibition impairs extinction memory reconsolidation

Radiske, Andressa; Gonzalez, Maria Carolina; Ferreira, Diana Aline Nôga Morais; Rossato, Janine Inez; Bevilaqua, Lia Rejane Müller; Cammarota, Martín Pablo

mTOR inhibition impairs extinction memory reconsolidation

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dc.contributor.author	Radiske, Andressa
dc.contributor.author	Gonzalez, Maria Carolina
dc.contributor.author	Ferreira, Diana Aline Nôga Morais
dc.contributor.author	Rossato, Janine Inez
dc.contributor.author	Bevilaqua, Lia Rejane Müller
dc.contributor.author	Cammarota, Martín Pablo
dc.date.accessioned	2021-01-07T18:24:54Z
dc.date.available	2021-01-07T18:24:54Z
dc.date.issued	2020-12-15
dc.description.resumo	Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibition. Our results demonstrate that mTOR signaling is necessary for fear-motivated avoidance extinction memory reconsolidation and suggests that BDNF acts downstream mTOR in a protein synthesis-independent manner to maintain the reactivated extinction memory trace	pt_BR
dc.identifier.citation	RADISKE, Andressa; GONZALEZ, Maria Carolina; NÔGA, Diana A.; ROSSATO, Janine I.; BEVILAQUA, Lia R. M.; CAMMAROTA, Martín. mTOR inhibition impairs extinction memory reconsolidation. Learning & Memory, [S. l.], v. 28, n. 1, p. 1-6, dez. 2020. doi: http://dx.doi.org/10.1101/lm.052068.120. Disponível em: http://learnmem.cshlp.org/content/28/1/1.abstract. Acesso em: 07 jan. 2021.	pt_BR
dc.identifier.doi	10.1101/lm.052068.120
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31230
dc.language	en	pt_BR
dc.publisher	Cold Spring Harbor Laboratory	pt_BR
dc.rights	Attribution-NonCommercial 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/3.0/br/	*
dc.subject	Memory reconsolidation	pt_BR
dc.subject	Brain-derived neurotrophic factor	pt_BR
dc.subject	BDNF	pt_BR
dc.subject	TOR Serine-threonine kinases	pt_BR
dc.subject	Mammalian target of rapamycin	pt_BR
dc.title	mTOR inhibition impairs extinction memory reconsolidation	pt_BR
dc.type	article	pt_BR