Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection

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dc.contributor.authorReis, Bruna Zavarize
dc.contributor.authorRibeiro, Heriks Gomes
dc.contributor.authorKomatsu, Raquel Costa Silva Dantas
dc.contributor.authorMedeiros, Jeane Franco Pires
dc.contributor.authorCarvalho, Maria Clara da Cruz
dc.contributor.authorSoares, Victor de Lima
dc.contributor.authorLuchessi, André Ducati
dc.contributor.authorSilbiger, Vivian Nogueira
dc.date.accessioned2024-03-01T22:05:31Z
dc.date.available2024-03-01T22:05:31Z
dc.date.issued2021-11
dc.description.resumoBackground: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2 infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate the 25-hydroxyvitamin D (25(OH)D) concentrations and lipid profile prior to the SARS-CoV-2 tests in a population from a sunny region in Brazil (5 degrees S, 35 degrees W). Methods: This retrospective cohort study enrolled 1634 patients tested for SARS-CoV-2 of a private medical laboratory with 25(OH)D concentration and lipid profile measured ≥ 7 days before the date of the first SARSCoV-2 RT-PCR test and were categorized according to 25(OH)D sufficiency (≥30 ng/mL) or insufficiency (<30 ng/mL). Multiple logistic regression analyses were performed to assess risk factors associated with positive tests for SARS-CoV-2. Results: Average serum 25(OH)D was 33.6 ng/mL. Vitamin D deficiency (<20 ng/mL) was only found in 2.6% of the participants. Multivariate analysis demonstrated that patients > 49 y with insufficient 25(OH)D (<30 ng/mL) presented increased odds to test positive for SARS-CoV-2 (OR: 2.02, 95 %CI: 1.15 to 3.55, P = 0.015). The same is observed among those with total cholesterol > 190 mg/dL (OR: 1.90, 95 %CI: 1.10 to 3.28, P = 0.020). Conclusions: Previous insufficient 25(OH)D (<30 ng/mL) concentration and high total cholesterol were associated with SARS-CoV-2 infection among adults > 48 y in the study population. Further studies should be conducted to confirm whether measurement of 25(OH)D and lipid profile could be useful to identify patients who are more susceptible to COVID-19pt_BR
dc.identifier.citationRIBEIRO, Heriks Gomes; KOMATSU, Raquel Costa Silva Dantas; MEDEIROS, Jeane Franco Pires; CARVALHO, Maria Clara da Cruz; SOARES, Victor de Lima; REIS, Bruna Zavarize; LUCHESSI, André Ducati; SILBIGER, Vivian Nogueira. Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection. Clinica Chimica Acta, [S.l.], v. 522, p. 8-13, nov. 2021. DOI: 10.1016/j.cca.2021.08.003. Disponível em: https://www.sciencedirect.com/science/article/pii/S0009898121002709?via%3Dihub. Acesso em: 19 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.cca.2021.08.003
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57733
dc.languageenpt_BR
dc.publisherClinica Chimica Actpt_BR
dc.subjectCOVID-19pt_BR
dc.subjectCholecalciferolpt_BR
dc.subjectLipid Profilept_BR
dc.subjectSARS-CoV-2pt_BR
dc.titlePrevious vitamin D status and total cholesterol are associated with SARS-CoV-2 infectionpt_BR
dc.typearticlept_BR

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