Effect of chronic stress during adolescence in prefrontal cortex structure and function

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dc.contributor.authorFolha, Otávio Augusto de Araújo Costa
dc.contributor.authorBahia, Carlomagno Pacheco
dc.contributor.authorAguiar, Gisele Priscila Soares de
dc.contributor.authorHerculano, Anderson Manoel
dc.contributor.authorCoelho, Nicole Leite Galvão
dc.contributor.authorSousa, Maria Bernardete Cordeiro de
dc.contributor.authorShiramizu, Victor Kenji Medeiros
dc.contributor.authorGalvão, Ana Cecília de Menezes
dc.contributor.authorCarvalho, Walther Augusto de
dc.contributor.authorPereira, Antonio
dc.date.accessioned2017-06-01T19:44:56Z
dc.date.available2017-06-01T19:44:56Z
dc.date.issued2017
dc.description.resumoCritical periods of plasticity (CPPs) are defined by developmental intervals wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal nets (PNNs) surrounding the cell bodies of specialized inhibitory interneurons. The aim of the present work was to evaluate the effect of chronic stress on both structure and function of the adolescent’s rat PFC. We subjected P28 rats to stressful situations for 7, 15 and 35 days and evaluated the spatial distribution of histochemically-labeled PNNs in both the Medial Prefrontal Cortex (MPFC) and the Orbitofrontal Cortex (OFC) and PFC-associated behavior as well. Chronic stress affects PFC development, slowing PNN maturation in both the (MPFC) and (OFC) while negatively affecting functions associated with these areas. We speculate upon the risks of prolonged exposure to stressful environments in human adolescents and the possibility of stunted development of executive functions.pt_BR
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23356
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPre-frontal cortexpt_BR
dc.subjectChronic stresspt_BR
dc.subjectPerineuronal netspt_BR
dc.subjectCritical periodpt_BR
dc.subjectPlasticitypt_BR
dc.titleEffect of chronic stress during adolescence in prefrontal cortex structure and functionpt_BR
dc.typearticlept_BR

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