XPA deficiency affects the ubiquitin-proteasome system function

Página do item simplificado Estatísticas
dc.contributor.authorLeal, Angélica Maria de Sousa
dc.contributor.authorMedeiros, Lázaro Batista de Azevedo
dc.contributor.authorMuñoz-Cadavid, Cesar Orlando
dc.contributor.authorOliveira, Riva de Paula
dc.contributor.authorTimóteo, Ana Rafaela de Souza
dc.contributor.authorOliveira, Ana Helena Sales de
dc.contributor.authorFaustino, André Luis Fonseca
dc.contributor.authorSilva, Vandeclécio Lira da
dc.contributor.authorSouza, Sandro José de
dc.contributor.authorLajus, Tirzah Braz Petta
dc.contributor.authorCampos, Julliane Tamara Araújo de Melo
dc.contributor.authorAgnez-Lima, Lucymara Fassarella
dc.date.accessioned2020-07-23T17:36:23Z
dc.date.available2020-07-23T17:36:23Z
dc.date.issued2020-07
dc.description.resumoXeroderma pigmentosum complementation group A (XPA), is defective in xeroderma pigmentosum patients, causing pre-disposition to skin cancer and neurological abnormalities, which is not well understood. Here, we analyzed the XPA-deficient cells transcriptional profile under oxidative stress. The imbalance in of ubiquitin-proteasome system (UPS) gene expression was observed in XPA-deficient cells and the involvement of nuclear factor erythroid 2-related factor-2 (NFE2L2) was indicated. Co-immunoprecipitation assays showed the interaction between XPA, apurinic-apyrimidinic endonuclease 1 (APE1) and NFE2L2 proteins. Decreased NFE2L2 protein expression and proteasome activity was also observed in XPA-deficient cells. The data suggest the involvement of the growth arrest and DNA-damage-inducible beta (GADD45β) in NFE2L2 functions. Similar results were obtained in xpa-1 (RNAi) Caenorhabditis elegans suggesting the conservation of XPA and NFE2L2 interactions. In conclusion, stress response activation occurs in XPA-deficient cells under oxidative stress; however, these cells fail to activate the UPS cytoprotective response, which may contribute to XPA patient’s phenotypes.pt_BR
dc.identifier.citationLEAL, Angélica Maria de Sousa; MEDEIROS, Lázaro Batista de Azevedo; MUÑOZ-CADAVID, Cesar Orlando; OLIVEIRA, Riva de Paula; TIMÓTEO, Ana Rafaela de Souza; OLIVEIRA, Ana Helena Sales de; FAUSTINO, André Luis Fonseca; SILVA, Vandeclécio Lira da; SOUZA, Sandro José de; LAJUS, Tirzah Braz Petta. XPA deficiency affects the ubiquitin-proteasome system function. Dna Repair, [S.L.], v. 94, p. 102937, out. 2020. http://dx.doi.org/10.1016/j.dnarep.2020.102937. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1568786420301865?via%3Dihub. Acesso em: 23 jul. 2020.pt_BR
dc.identifier.doi10.1016/j.dnarep.2020.102937
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/29716
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectXeroderma pigmentosumpt_BR
dc.subjectOxidative stresspt_BR
dc.subjectXeroderma Pigmentosum Group A Proteinpt_BR
dc.subjectApurinic-apyrimidinic endonuclease 1 (APE1)pt_BR
dc.subjectNF-E2-Related Factor 2pt_BR
dc.subjectTranscriptional regulationpt_BR
dc.subjectProteolysispt_BR
dc.subjectProteostasispt_BR
dc.subjectProteasomept_BR
dc.titleXPA deficiency affects the ubiquitin-proteasome system functionpt_BR
dc.typearticlept_BR

Arquivos

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM