Anticonvulsant effects of fractions isolated from dinoponera quadriceps (Kempt) ant venom (Formicidae: ponerinae)

Página do item simplificado Estatísticas
dc.contributor.authorNôga, Diana Aline Morais Ferreira
dc.contributor.authorBrandão, Luiz Eduardo Mateus
dc.contributor.authorCagni, Fernanda Carvalho
dc.contributor.authorSilva, Delano
dc.contributor.authorAzevedo, Dina Lilia Oliveira de
dc.contributor.authorAraújo, Arrilton
dc.contributor.authorSantos, Wagner Ferreira dos
dc.contributor.authorMiranda, Antonio
dc.contributor.authorSilva, Regina Helena da
dc.contributor.authorRibeiro, Alessandra Mussi
dc.date.accessioned2018-01-24T20:14:51Z
dc.date.available2018-01-24T20:14:51Z
dc.date.issued2017
dc.description.resumoNatural products, sources of new pharmacological substances, have large chemical diversity and architectural complexity. In this context, some toxins obtained from invertebrate venoms have anticonvulsant effects. Epilepsy is a neurological disorder that affects about 65 million people worldwide, and approximately 30% of cases are resistant to pharmacological treatment. Previous studies from our group show that the denatured venom of the ant Dinoponera quadriceps (Kempt) protects mice against bicuculline (BIC)-induced seizures and death. The aim of this study was to investigate the anticonvulsant activity of compounds isolated from D. quadriceps venom against seizures induced by BIC in mice. Crude venom was fractionated by high-performance liquid chromatography (HPLC) resulting in six fractions referred to as DqTx1–DqTx6. A liquid chromatography-mass spectrometry (LC/MS) analysis revealed a major 431 Da compound in fractions DqTx1 and DqTx2. Fractions DqTx3 and DqTx4 showed a compound of 2451 Da and DqTx5 revealed a 2436 Da compound. Furthermore, the DqTx6 fraction exhibited a major component with a molecular weight of 13,196 Da. Each fraction (1 mg/mL) was microinjected into the lateral ventricle of mice, and the animals were observed in an open field. We did not observe behavioral alterations when the fractions were given alone. Conversely, when the fractions were microinjected 20 min prior to the administration of BIC (21.6 nM), DqTx1, DqTx4, and DqTx6 fractions increased the latency for onset of tonic-clonic seizures. Moreover, all fractions, except DqTx5, increased latency to death. The more relevant result was obtained with the DqTx6 fraction, which protected 62.5% of the animals against tonic-clonic seizures. Furthermore, this fraction protected 100% of the animals from seizure episodes followed by death. Taken together, these findings indicate that compounds from ant venom might be a potential source of new anticonvulsants moleculespt_BR
dc.identifier.citationNÔGA, Diana Aline Morais Ferreira et al. Anticonvulsant effects of fractions isolated from dinoponera quadriceps (Kempt) ant venom (Formicidae: ponerinae). Toxins, v. 9, n.1, 2017. Disponível em:<http://www.mdpi.com/2072-6651/9/1/5>. Acesso em: 18 out. 2017.pt_BR
dc.identifier.doi10.3390/toxins9010005
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/24650
dc.languageengpt_BR
dc.publisherMultidisciplinary Digital Publishing Institutept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAnt venompt_BR
dc.subjectNeuroactive compoundspt_BR
dc.subjectBicucullinept_BR
dc.subjectTonic-clonicpt_BR
dc.subjectPeptide fractionpt_BR
dc.subjectNatural productpt_BR
dc.titleAnticonvulsant effects of fractions isolated from dinoponera quadriceps (Kempt) ant venom (Formicidae: ponerinae)pt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
AnticonvulsantEffectsFractions_Noga_2017.pdf
Tamanho:
2.18 MB
Formato:
Adobe Portable Document Format
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

CB - DBIO - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM