Avaliação da toxicidade aguda e eficácia anti-inflamatória do extrato hidroetanólico das raízes da Harpalyce brasiliana Benth no edema de pata induzido por carragenina

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dc.contributor.advisorAraújo, Renata Mendonça de
dc.contributor.advisor-co1Torres-Rêgo, Manoela
dc.contributor.advisor-co1ID0000-0002-8535-1533pt_BR
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/0735782214033188pt_BR
dc.contributor.advisorID0000-0001-5514-5192pt_BR
dc.contributor.advisorLatteshttp://lattes.cnpq.br/4163879756935913pt_BR
dc.contributor.authorRocha, Enos
dc.contributor.authorID0000-0002-5148-9630pt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/5043323418030972pt_BR
dc.contributor.referees1Passos, Júlia Gabriela Ramos
dc.contributor.referees1ID0000-0003-4207-9709pt_BR
dc.contributor.referees1Latteshttp://lattes.cnpq.br/1969453327313987pt_BR
dc.contributor.referees2Medeiros, Renato Dantas de
dc.contributor.referees2ID0000-0003-2208-7808pt_BR
dc.contributor.referees2Latteshttp://lattes.cnpq.br/9604683278634721pt_BR
dc.date.accessioned2021-09-10T19:03:27Z
dc.date.available2021-09-10T19:03:27Z
dc.date.issued2021-08-23
dc.description.resumoHarpalyce brasiliana Benth (Leguminoseae), a small tree endemic to the north and northeast of Brazil, popularly known as “snake root”. In folk medicine is used for the treatment of inflammation and snakebites, but there is a shortage of studies that justify its use in popular medicine. So, this study aims to evaluate the cytotoxicity, acute toxicity and anti-inflammatory potential of H. brasiliana root extracts in in vivo model. The cytotoxicity of the extract was analyzed through of hemolytic assay, using doses of 31-2000 µg/mL of extract, and the results demonstrated be safe. The acute toxicity test in vivo was performed through of administration of the of 2000 mg/kg of extract, by gavage route. The animals were observed for 14 days and, at the end of the period, the body and organs were weight and the hematological and biochemical parameters were verified and its was evidenced that not showed alterations significative. For the anti-inflammatory activity in vivo, the carrageenan-induced paw edema model was used. The mice received carrageenan intraplanar and simultaneously was treated, by gavage route, with extract at doses of 100, 200 and 400 mg/kg. In this assay, the extract revealed to decrease of paw edema and myeloperoxidase level. For the first time, our data demonstrate that the hydroethanolic extract from H. brasiliana roots is not cytotoxic, has low toxicity in vivo and has anti-inflammatory effect in preclinical analyses, corroborated its use in folk medicine.pt_BR
dc.description.sponsorshipCNPQpt_BR
dc.identifier.citationROCHA, Enos. Avaliação da toxicidade aguda e eficácia anti-inflamatória do extrato hidroetanólico das raízes da Harpalyce brasiliana benth no edema de pata induzido por carragenina. 2021. 54f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2021.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/33355
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentDepartamento de Farmáciapt_BR
dc.publisher.initialsUFRNpt_BR
dc.publisher.programFarmáciapt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectSnake root, Cytotoxicity, Acute toxicity, Anti-inflammatory, Harpalyce brasiliana, Pterocarpanspt_BR
dc.titleAvaliação da toxicidade aguda e eficácia anti-inflamatória do extrato hidroetanólico das raízes da Harpalyce brasiliana Benth no edema de pata induzido por carrageninapt_BR
dc.title.alternativeToxicity acute evaluation and anti-inflammatory efficacy of hydroethanolic extract of Harpalyce brasiliana Benth roots in carrageenan-induced paw edemapt_BR
dc.typebachelorThesispt_BR

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