Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

Silva, Vandeclécio Lira da; Fonseca, André Faustino; Fonseca, Marbella M.; Silva, Thayna Emília da; Coelho, Ana Carolina; Kroll, José Eduardo; Souza, Jorge Estefano Santana de; Ferreira, Beatriz Stransky; Souza, Gustavo Antônio de; Souza, Sandro José de

Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

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dc.contributor.author	Silva, Vandeclécio Lira da
dc.contributor.author	Fonseca, André Faustino
dc.contributor.author	Fonseca, Marbella M.
dc.contributor.author	Silva, Thayna Emília da
dc.contributor.author	Coelho, Ana Carolina
dc.contributor.author	Kroll, José Eduardo
dc.contributor.author	Souza, Jorge Estefano Santana de
dc.contributor.author	Ferreira, Beatriz Stransky
dc.contributor.author	Souza, Gustavo Antônio de
dc.contributor.author	Souza, Sandro José de
dc.date.accessioned	2020-07-13T16:36:27Z
dc.date.available	2020-07-13T16:36:27Z
dc.date.issued	2017-10-10
dc.description.resumo	Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma	pt_BR
dc.identifier.citation	SILVA, V.; FONSECA, A.; FONSECA, M. ; SILVA, T.; COELHO, A.; KROLL, J.; SOUZA, J.; FERREIRA, B. S.;SOUZA, G.; SOUZA, S.. Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. Oncotarget, v. 8, p. 92966-92977, 2017. Disponível em: https://www.oncotarget.com/article/21715/text/. Acesso em: 10 jul. 2020. https://doi.org/10.18632/oncotarget.21715	pt_BR
dc.identifier.doi	10.18632/oncotarget.21715
dc.identifier.issn	1949-2553
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/29575
dc.language	en	pt_BR
dc.publisher	Impact Journals	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Cancer/testis	pt_BR
dc.subject	Cancer antigens	pt_BR
dc.subject	Biomarkers	pt_BR
dc.subject	Prognosis	pt_BR
dc.title	Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis	pt_BR
dc.type	article	pt_BR